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Planar patch clamp device and planar patch clamp system

Foreign code F170009196
File No. AF19-07WO
Posted date Sep 12, 2017
Country Republic of Korea
Application number 20167005553
Gazette No. 20160040647
Date of filing Aug 29, 2014
Gazette Date Apr 14, 2016
International application number JP2014072808
International publication number WO2015030201
Date of international filing Aug 29, 2014
Date of international publication Mar 5, 2015
Priority data
  • P2013-180684 (Aug 30, 2013) JP
  • 2014WO-JP72808 (Aug 29, 2014) WO
Title Planar patch clamp device and planar patch clamp system
Abstract (KR20160040647)
A planar patch clamp device comprising: an electrical insulating substrate (2) having a first surface having a cell arrangement region and a second surface of the opposite surface and having a through hole (3) in the cell arrangement region which does not pass cells, but pass liquid; a first reservoir (6) provided at the first surface side (2S) of the electrical insulating substrate (2) to be able to communicate with the through hole (3) and hold a first conductive liquid; a first electrode part (7) arranged to be able to be electrically conductive with the first reservoir (6) through the first conductive liquid; a second reservoir (6') provided at the second surface side (2S') of the electrical insulating substrate to be able to communicate with the through hole (3) and hold a second conductive liquid; a second electrode part (7') arranged to be able to be electrically conductive with the second reservoir (6') through the second conductive liquid; a supply path (8) connected to the second reservoir (6') and supplying the second conductive liquid to the second reservoir; a discharge path (9) connected to the second reservoir and discharging the second conductive liquid from the second reservoir (6'); and a valve (10) provided in the supply path and/or discharge path, able to allow or stop the flow of the second conductive liquid, and also able to allow or stop electrical conduction between the second reservoir (6') and the second electrode part (7').
(From EP3040410 A1)
Scope of claims [claim1]
1. Will have the second surface which is a first surface which has a cell arrangement territory and that reverse side, although within cell arrangement territory the cell at the time of passage height, the liquid will be able to pass with the electric dielectric board which has the penetration hole,
The penetration hole and the chimney possibly from first ostensible side of the electric dielectric borad, to be established, possesses the first defiant liquid the first misfortune type father for and,
The first misfortune type father and the first defiant liquid leads, electric continuity possibly, the first electrode department which is arranged and,
The penetration hole and the chimney possibly from second ostensible side of the electric dielectric borad, to be established, possesses the second defiant liquid the second misfortune type father for and,
The second misfortune type father and the second defiant liquid leads, electric continuity possibly, the second electrode department which is arranged and,
To be connected to the second misfortune type father, to the second misfortune type father the second defiant liquid as for low of the Song sum the Song sum euro and,
To be connected to the second misfortune type father, from the second misfortune type father the second defiant liquid as for under the drainage the drainage euro and,
The Song sum euro and/or to be established to the drainage euro, circulation of the second defiant liquid permission or will be able to stand still, at the same time, electric continuity with the second misfortune type father and the second electrode department permission or will be able to stand still the planner patch clamp equipment which has the valve.
[claim2]
2. There is in a 1st claim,
The electric dielectric board cell arrangement territory and as for under confronting multiple has the penetration hole respectively to it, at the same time, about under confronting second misfortune type additional multiple is established to cell arrangement territory of multiple,
The Song sum euro, from the Song sum week euro and the Song sum week euro to diverge, has the Song sum euro of the multiple which is respectively connected to the second misfortune type father of multiple,
The drainage euro, the drainage euro of the drainage euro and revenge of the multiple which is respectively connected to the second misfortune type father of multiple as for under being confluence to have the drainage week euro, and
With second electrode addition and Song sum oiling and/or is established to the drainage week euro,
The valve, although each Song sum euro and/or runs wild to each drainage euro, the planner patch clamp equipment.
[claim3]
3. The 1st claim or there is in a 2nd claim,
There is in at the time of valve closing and electrical resistance price around the valve 1 mega the planner patch clamp equipment which is an above coming.
[claim4]
4. The 1st claim to in the 3rd claim the planner patch clamp equipment which is recorded to which one claim and,
Opening and shutting each valve of minute description planner patch clamp equipment as for under controlling control department and,
There is in each electrode department of the minute description planner patch clamp equipment, electric signal as for under detecting the electric primary means as for under having planner patch clamp system.
[claim5]
5. There is in a 4th claim,
Minute description planner patch clamp equipment as for under multiple having planner patch clamp system.
[claim6]
6. The 4th claim or there is in a 5th claim,
As for under being originated fanaticism issue as for under detecting the storehouse primary means more to the cell which is arranged to the minute description planner patch clamp equipment the low of having planner patch clamp system.
[claim7]
7. The 1st claim to in the 3rd claim the planner patch clamp equipment which is recorded to which one claim or the 4th claim to in the 7th claim the planner patch clamp system which is recorded to which one claim about under using, the medicine which influences to the nervous network as for under screening method.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • URISU TSUNEO
  • WANG ZHI HONG
  • UNO HIDETAKA
  • NAGAOKA YASUTAKA
  • KOBAYASHI KEI
IPC(International Patent Classification)
Reference ( R and D project ) CREST Creation of Nanosystems with Novel Functions through Process Integration AREA
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