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Anticancer agent

Foreign code F170009202
File No. AF12-12WO
Posted date Sep 12, 2017
Country EPO
Application number 13758278
Gazette No. 2837387
Date of filing Mar 5, 2013
Gazette Date Feb 18, 2015
International application number JP2013055927
International publication number WO2013133253
Date of international filing Mar 5, 2013
Date of international publication Sep 12, 2013
Priority data
  • P2012-052334 (Mar 8, 2012) JP
  • 2013WO-JP55927 (Mar 5, 2013) WO
Title Anticancer agent
Abstract (EP2837387)
According to the present invention, an anticancer agent is provided that has as an active ingredient thereof a human antibody light chain that demonstrates cytotoxicity against cancer cells and particularly lung cancer cells.
The anticancer agent of the present invention primarily comprises: a human antibody º-type light chain in the form of a dimer in which the variable region is composed of a polypeptide represented by the amino acid sequence of SEQ ID NO: 1, 9 or 13 or an amino acid sequence in which one or a plurality of amino acids have been added, deleted or substituted in these amino acid sequences; or, a human antibody º-type light chain in the form of a monomer in which the variable region is composed of a polypeptide represented by the amino acid sequence of SEQ ID NO: 19 or an amino acid sequence in which one or a plurality of amino acids have been added, deleted or substituted in the amino acid sequence.
Scope of claims [claim1]
1. An anticancer agent, comprising: (1) a human antibody kappa -type light chain in the form of a dimer in which a variable region is composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 1, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence; (2) a human antibody kappa -type light chain in the form of a dimer in which a variable region is composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 7, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence; (3) a human antibody kappa -type light chain in the form of a dimer in which a variable region is composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 9, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence; (4) a human antibody kappa -type light chain in the form of a dimer in which a variable region is composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 13, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence; (5) a human antibody kappa -type light chain in the form of a monomer in which a variable region is composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 19, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence; (6) a human antibody kappa -type light chain in the form of a monomer in which a variable region is composed of a polypeptide represented by an amino acid sequence consisting of the 1st to 113th amino acids of SEQ ID NO: 38, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence; (7) a human antibody kappa -type light chain in the form of a dimer in which a variable region is composed of a polypeptide represented by an amino acid sequence consisting of the 1st to 112th amino acids of SEQ ID NO: 40, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence; or (8) a human antibody kappa -type light chain in the form of a dimer in which a variable region is composed of a polypeptide represented by an amino acid sequence consisting of the 1st to 107th amino acids of SEQ ID NO: 41, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence.
[claim2]
2. The anticancer agent according to claim 1, wherein
the human antibody kappa -type light chain of (1) above is a human antibody kappa -type light chain in the form of a dimer composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 2, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence;
the human antibody kappa -type light chain of (2) above is a human antibody kappa -type light chain in the form of a dimer composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 8, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence;
the human antibody kappa -type light chain of (3) above is a human antibody kappa -type light chain in the form of a dimer composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 10, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence;
the human antibody kappa -type light chain of (4) above is a human antibody kappa -type light chain in the form of a dimer composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 14, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence;
the human antibody kappa -type light chain of (5) above is a human antibody kappa -type light chain in the form of a monomer composed of a polypeptide represented by an amino acid sequence in which cysteine at position 219 has been deleted or substituted by an amino acid other than cysteine in the amino acid sequence of SEQ ID NO: 20, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence;
the human antibody kappa -type light chain of (6) above is a human antibody kappa -type light chain in the form of a monomer composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 38, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence;
the human antibody kappa -type light chain of (7) above is a human antibody kappa -type light chain in the form of a dimer composed of a polypeptide represented by the amino acid sequence of SEQ ID NO: 40, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence; or
the human antibody kappa -type light chain of (8) above is a human antibody kappa -type light chain in the form of a dimer composed of a polypeptide represented by an amino acid sequence of SEQ ID NO: 41, an amino acid sequence in which one or a plurality of the amino acids in the amino acid sequence have been substituted, added or deleted, or an amino acid sequence having homology of 95% or more with the amino acid sequence.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • UDA TAIZO
  • HIFUMI EMI
IPC(International Patent Classification)
Specified countries (EP2837387)
Contracting States: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Reference ( R and D project ) CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA
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