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Planar patch clamp device and planar patch clamp system NEW

外国特許コード F170009218
整理番号 AF19-07WO
掲載日 2017年9月13日
出願国 中華人民共和国
出願番号 201480048002
公報番号 105555945
出願日 平成26年8月29日(2014.8.29)
公報発行日 平成28年5月4日(2016.5.4)
国際出願番号 JP2014072808
国際公開番号 WO2015030201
国際出願日 平成26年8月29日(2014.8.29)
国際公開日 平成27年3月5日(2015.3.5)
優先権データ
  • 特願2013-180684 (2013.8.30) JP
  • 2014WO-JP72808 (2014.8.29) WO
発明の名称 (英語) Planar patch clamp device and planar patch clamp system NEW
発明の概要(英語) (CN105555945)
A planar patch clamp device comprising: an electrically non-conductive substrate (2) having a through-hole (3) which passes liquid yet does not pass cells in a cell arrangement region (4); a first liquid reservoir unit (6) for holding a first electroconductive liquid, the first liquid reservoir unit (6) being provided so as to allow communication with the through-hole (3) on a first surface (2S) of the substrate (2); a first electrode unit (7) arranged so as to allow electrical conductivity with the first liquid reservoir unit (6); a second liquid reservoir unit (6') for holding a second electroconductive liquid, the second liquid reservoir unit (6) being provided so as to allow communication with the through-hole (3) on a second surface (2S') of the substrate (2); a second electrode unit (7') arranged so as to allow electrical conductivity with the first liquid reservoir unit (6); a liquid feed channel (8) for feeding the second electroconductive liquid to the second liquid reservoir unit (6'); a liquid discharge channel (9) for discharging the second electroconductive liquid from the second liquid reservoir unit (6'); and a valve (10) disposed in the liquid feed channel (8) and/or the liquid discharge channel (9), the valve (10) being capable of permitting or stopping the distribution of the second electroconductive liquid, and permitting or stopping electrical conductivity with the second liquid reservoir unit (6') and the second electrode unit (7').
特許請求の範囲(英語) [claim1]
1. A planar patch clamp device, having:
An electrically insulating substrate, which includes the 1st surface and as the 1st cell placement surface region of an opposite surface from 2nd surface, and electrically insulating substrate through the cells in the cell arrangement area having a non-liquid but can be made through a through hole;
1st sump portion, wherein the through-hole provided in communicating manner so as to be in an electrically insulating substrate with a 1st surface side, and serves to maintain 1st conductive liquid;
1st electrode unit, configured to be capable device supplying electric conduction to the 1st through the 1st conductive liquid;
2nd sump portion, wherein the through-hole provided in communicating manner so as to be in an electrically insulating substrate with a 2nd surface side, 2nd and serves to maintain the conductive liquid;
2nd electrode unit, configured to be capable 2nd conductive liquid via electrical communication with the 2nd liquid storage portion;
Send flow path, which is connected with the sump portion 2nd, 2nd conductive liquid delivery reservoir and to 2nd;
A drainage flow path, which is connected with the sump portion 2nd, 2nd 2nd conductive liquid discharged from the reservoir; and
Valve, and/or send flow path which is disposed in the drainage flow path, it is possible to allow or stop the flow of liquid conductive 2nd, 2nd electrode portion with the reservoir and can allow or stop the 2nd electrical conduction.
[claim2]
2. The planar patch clamp device according to claim 1, wherein,
An electrically insulating substrate and respectively having a plurality of cell arrangement area with a plurality of cell arrangement area corresponding through hole, and electrically insulating substrate with a plurality of cells provided in correspondence with a plurality of 2nd reservoir mounting region,
Send flow path having: feeding the main passage, and from the liquid feed main flow path is branched and connected respectively to the plurality of 2nd device supplying a plurality of liquid-feeding flow paths,
A drainage flow path having: a plurality of connected respectively to the plurality of 2nd reservoir drainage branch flow path, and a plurality of drainage tributary drainage sum of the main passage,
2nd electrode portion is provided in the main flow path and/or drain liquid prepared by the main passage,
Each valve is provided in and/or the drainage liquid feeding branch flow path branch flow path.
[claim3]
3. The planar patch clamp device according to claim 1 or 2, wherein,
Has a value of 1 before and after a valve when the valve closes more than mega ohms.
[claim4]
4. A planar patch clamp system, comprising:
Claim 1 to 3 according to any one of the planar patch clamp device;
The control plane of opening and closing of the valves of the patch-clamp device control unit; and
Planar patch clamp device according to the detection electrode portion of an electrical signal-charge detection unit.
[claim5]
5. The planar patch clamp system according to claim 4, wherein,
The planar patch clamp system includes a plurality of patch-clamp device.
[claim6]
6. The planar patch clamp system according to claim 4 or 5, wherein,
The planar patch clamp system further includes a light detector, light detector detecting light from the patch-clamp device disposed in a plane of cells in light signal.
[claim7]
7. One method, the use of planar patch clamp device as claimed in any claim 1 to 3, or according to any one of claim 4 to 7 planar patch clamp system, for screening an agent for the neural network.
  • 出願人(英語)
  • LIEBHERR
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • ANDREAS ORLEAN
  • URISU TSUNEO
  • WANG ZHI-HONG
  • UNO HIDETAKA
  • NAGAOKA YASUTAKA
  • KOBAYASHI KEI
国際特許分類(IPC)
参考情報 (研究プロジェクト等) CREST Creation of Nanosystems with Novel Functions through Process Integration AREA
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