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IRRADIATION DEVICE, LASER MICROSCOPE SYSTEM, IRRADIATION METHOD, AND LASER MICROSCOPE DETECTION METHOD NEW

外国特許コード F170009228
整理番号 IP02P002
掲載日 2017年9月14日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP004801
国際公開番号 WO 2017138619
国際出願日 平成29年2月9日(2017.2.9)
国際公開日 平成29年8月17日(2017.8.17)
優先権データ
  • 特願2016-022607 (2016.2.9) JP
発明の名称 (英語) IRRADIATION DEVICE, LASER MICROSCOPE SYSTEM, IRRADIATION METHOD, AND LASER MICROSCOPE DETECTION METHOD NEW
発明の概要(英語) Provided are an irradiation device, a laser microscope system, an irradiation method, and a laser microscope detection method with which the bandwidth of detection light in the form of multiplexed signals can be increased. According to the present invention, laser light beams are separated and caused to enter a first AOD (24) and a second AOD (34) to generate a plurality of beams of first diffracted light and second diffracted light which have different angles of deflection and different levels of frequency shift. A beam splitter (19) superimposes the first diffracted light beams and the second diffracted light beams on each other to generate multiple interfering light beams which have different beat frequencies. An object lens (52) linearly aligns irradiation spots of the multiple interfering light beams in a main scanning direction and irradiates a sample (T) with the interfering light beams. Oscillation of a scan mirror (47a) causes the irradiation spots to move in a sub-scanning direction orthogonal to the main scanning direction. A light detection unit (13) detects fluorescent light emitted from the sample (T) irradiated with the respective interfering light beams.
特許請求の範囲(英語) [claim1]
1. Plural 2nd lights of the frequency which differs from the plural 1st lights of the frequency differing mutually mutually, interfering with the combination where difference of frequency of the aforementioned 1st light and the aforementioned 2nd light differs depending, the interference optical formation department which forms the plural interference lights where beat frequency differs and,
The interference optical lighting section which irradiates plural aforementioned interference lights
The lighting device which features that it has.
[claim2]
2. The 1st acousto-Optics acoustooptics deflector which ejects the plural diffracted light which respond to the frequency of the COM signal to which the aforementioned interference optical formation department makes the light diffract which is output from the laser illuminant, is input as plural aforementioned 1st lights and,
The 2nd acousto-Optics acoustooptics deflector which ejects the plural diffracted light which respond to the frequency of the COM signal which makes the aforementioned light diffract which is output from the aforementioned laser illuminant, is input as plural aforementioned 2nd lights
In the claim 1 which features that it has the lighting device of statement.
[claim3]
3. The acousto-Optics acoustooptics frequency shifter which ejects the light where the aforementioned light from the aforementioned laser illuminant is done, incidence converts the frequency of the aforementioned light furthermore having,
As for the aforementioned 2nd acousto-Optics acoustooptics deflector, the aforementioned light where frequency is converted with the aforementioned acousto-Optics acoustooptics frequency shifter incidence in the claim 2 which features that it is done the lighting device of statement.
[claim4]
4. As for the aforementioned 1st acousto-Optics acoustooptics deflector and the aforementioned 2nd acousto-Optics acoustooptics deflector, contiguity or 1st light of the position where it is far and in the claim 2 which features that the aforementioned COM signal where each COM component is set to the phase which controls the crosstalk component by the interference of 2nd light is input or 3 the lighting device of statement.
[claim5]
5. In the claim 1 which features that it possesses the acousto-Optics acoustooptics deflector where the aforementioned interference optical formation department incidence is done respectively with the incident angle where the light which is output from the laser illuminant differs plus and minus, ejects the plural diffracted light of 2 sets which respond to the frequency of the COM signal as plural aforementioned 1st lights and plural aforementioned 2nd lights the lighting device of statement.
[claim6]
6. The aforementioned light from the aforementioned laser illuminant is done, diffracts incidence transmitted light of the transmitted component of the aforementioned light which incidence is done and, and the acousto-Optics acoustooptics frequency shifter which ejects the conversion light of the component where frequency is converted furthermore having,
The aforementioned acousto-Optics acoustooptics deflector incidence is done with the incident angle where plus and minus differ from the aforementioned transmitted light and the aforementioned conversion light
In the claim 5 which features thing the lighting device of statement.
[claim7]
7. 1st frequency range of plural aforementioned 1st lights and 2nd frequency range of plural aforementioned 2nd lights differing,
As for the aforementioned interference optical formation department, the claim either 1 which features that plural aforementioned interference lights are formed combining with the aforementioned 1st light and the aforementioned 2nd light which from those whose frequency is high from those whose frequency is low concerning plural aforementioned 1st lights, concerning plural aforementioned 2nd lights respectively are selected to order or 6 in 1 sections the lighting device of statement.
[claim8]
8. The 1st frequency range of plural aforementioned 1st lights and 2nd frequency range of plural aforementioned 2nd lights, the claim 1 which features that the frequency range is not piled up or either of 7 in 1 sections the lighting device of statement.
[claim9]
9. As for the aforementioned interference optical lighting section, arranging spot of plural aforementioned interference lights into line condition, claim 1 which features that it irradiates or either of 8 in 1 sections the lighting device of statement.
[claim10]
10. As for the aforementioned interference optical lighting section, with the incidence of plural aforementioned 1st lights and the plural aforementioned 2nd lights which line up with the same pitch, in lighting position of the aforementioned interference light the respective spot of plural aforementioned 1st lights and plural aforementioned 2nd lights with the same arrangement pitch arranging to line condition,
The claim either 1 which features that relative position of plural aforementioned 1st lights and plural aforementioned 2nd lights is shifted in the shifting quantity and the direction where the aforementioned interference optical formation department just half of the aforementioned arrangement pitch shifts the position of spot of the aforementioned 2nd light for the spot of the aforementioned 1st light at lighting position of the aforementioned interference light in the direction where spot lines up, forms the spot of the aforementioned 1st light and the spot of the aforementioned interference light where is piled up with the spot of the aforementioned 2nd light or 6 in 1 sections the lighting device of statement.
[claim11]
11. In claim 9 or 10 lighting device of statement and,
The laser microscope system which features that it has the photodetector which detects the detection light which it occurs by the fact that the aforementioned interference light is irradiated to the sample.
[claim12]
12. In the direction where spot of plural aforementioned interference lights lines up and the direction which is crossed, in the claim 11 which features that it has the scan section which makes with the spot and the aforementioned sample move of plural aforementioned interference lights relatively the laser microscope system of statement.
[claim13]
13. As for the aforementioned scan section, the aforementioned sample with the fluid is the flow cell which possesses the passage which can flow,
As for the aforementioned interference optical lighting section, inside the aforementioned passage the aforementioned spot in the claim 12 which features that it arranges into the machine direction the aforementioned sample and the direction which is crossed the laser microscope system of statement.
[claim14]
14. Having the wave length separated section which is separated into the wave length component of 2 or more detection light from the aforementioned sample according to wave length,
As for the aforementioned photodetector, the claim either 11 which features that it is provided in every wave length component which is separated by the aforementioned wave length separated section or 13 in 1 sections the laser microscope system of statement.
[claim15]
15. The diffracted light formation step which forms the plural 2nd lights of the frequency which differs from the plural 1st lights of the frequency which differs mutually mutually and,
Interfering with plural aforementioned 1st lights and plural aforementioned 2nd lights depending, the interference optical formation step which forms the plural interference lights where beat frequency differs and,
The lighting step which irradiates plural aforementioned interference lights
The lighting method of featuring that it possesses.
[claim16]
16. 1st frequency range of plural aforementioned 1st lights and 2nd frequency range of plural aforementioned 2nd lights differing,
As for the aforementioned interference optical formation step, in the claim 15 which features that plural aforementioned interference lights are formed combining with the aforementioned 1st light and the aforementioned 2nd light which from those whose frequency is high from those whose frequency is low concerning plural aforementioned 1st lights, concerning plural aforementioned 2nd lights respectively are selected to order lighting method of statement.
[claim17]
17. In the claim 15 which features that the plural 2nd diffracted light which respond to the frequency of the COM signal where incidence designating the light which is output from the laser illuminant, as the 1st acousto-Optics acoustooptics deflector and the 2nd acousto-Optics acoustooptics deflector respectively, it makes the aforementioned diffracted light formation step diffract, forms the plural 1st diffracted light which respond to the frequency of the COM signal which is input as plural aforementioned 1st lights, with the aforementioned 1st acousto-Optics acoustooptics deflector, is input as plural aforementioned 2nd lights, are formed with the aforementioned 2nd acousto-Optics acoustooptics deflector or 16 lighting method of statement.
[claim18]
18. As for the aforementioned diffracted light formation step, contiguity or 1st light of the position where it is far and the aforementioned COM signal where each COM component is set to the phase which controls the crosstalk component by the interference of 2nd light, in the claim 17 which features that it inputs into the aforementioned 1st acousto-Optics acoustooptics deflector and the aforementioned 2nd acousto-Optics acoustooptics deflector lighting method of statement.
[claim19]
19. In the claim 15 which features that the light which is output from the laser illuminant with the incident angle where plus and minus differs incidence it does the aforementioned diffracted light formation step, in the acousto-Optics acoustooptics deflector, it ejects the plural diffracted light of 2 sets which respond to the frequency of the COM signal as plural aforementioned 1st lights and plural aforementioned 2nd lights or 16 lighting method of statement.
[claim20]
20. The diffracted light formation step which forms the plural 2nd lights of the frequency which differs from the plural 1st lights of the frequency which differs mutually mutually and,
Interfering with plural aforementioned 1st lights and plural aforementioned 2nd lights depending, the interference optical formation step which forms the plural interference lights where beat frequency differs and,
The lighting step which irradiates plural aforementioned interference lights and,
Method of detection of the laser microscope which features that it possesses the optical detection step which detects the detection light which it occurs by the fact that the aforementioned interference light is irradiated to the sample.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • MIKAMI HIDEHARU
  • GODA KEISUKE
国際特許分類(IPC)
指定国 (WO2017138619)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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