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AQUAPORIN 4 FUNCTION PROMOTER AND PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS NEW

外国特許コード F170009244
整理番号 (S2016-0325-N0)
掲載日 2017年9月21日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP008485
国際公開番号 WO 2017150704
国際出願日 平成29年3月3日(2017.3.3)
国際公開日 平成29年9月8日(2017.9.8)
優先権データ
  • 特願2016-042766 (2016.3.4) JP
発明の名称 (英語) AQUAPORIN 4 FUNCTION PROMOTER AND PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS NEW
発明の概要(英語) An aquaporin 4 function promoter contains, as an active ingredient, a compound represented by general formula (1) or (2) or a pharmacologically acceptable salt thereof. (In the formulas, n11 is an integer of 1-10. R21 is a C1-10 alkyl group, alicyclic heterocyclic group, aromatic hydrocarbon group, or aromatic heterocyclic group.)
特許請求の範囲(英語) [claim1]
1. The below-mentioned general formula the chemical compound which is displayed with (1), or that the akuaporin 4 functional accelerator which features that it contains the salt which can be allowed pharmacy as the active ingredient.
(In formula, n (11) it is integer of the 1-10.)
[claim2]
2. The aforementioned chemical compound 2 - in the claim 1 which is guanidinoacetic - 1 - ethane sulfonic acid or 2 the akuaporin 4 functional accelerator of statement.
[claim3]
3. Either of the claim 1-3 the medicine composition for the nervous disease which features that inside the akuaporin 4 functional accelerator of statement, and the carrier and the diluent which can be allowed pharmacy at least each of them is included in one section.
[claim4]
4. In each case the aforementioned nervous disease is chosen from the Alzheimer's disease, the brain blockage and the group which consists of the encephaloma it is one, in claim 4 the medicine composition for the nervous disease of statement.
[claim5]
5. The below-mentioned general formula the chemical compound which is displayed with (2), or that the akuaporin 4 functional accelerator which features that it contains the salt which can be allowed pharmacy as the active ingredient.
(In formula, R (21) the alkyl group of the carbon count 1-10, it is the fat cyclic complex ring basis, the aromatic hydrocarbon radical or the aromatic complex ring basis.)
[claim6]
6. The description above R (21) the methyl group, the ethyl group, the n-puropiru basis, the i-puropiru basis, the n-buchiru basis, the i-buchiru basis, the sec-buchiru basis, the n-penchiru basis, the i-penchiru basis, the n-hekishiru basis, the shikuropuropiru basis, the shikurobuchiru basis, the cyclopentyl basis and the shikurohekishiru basis, 2 - the pirorijiniru basis, 3 - the pirorijiniru basis, 2 - the tetorahidorohuraniru basis, 3 - the tetorahidorohuraniru basis, 2 - the pyro rill basis, 3 - the pyro rill basis, 2 - the huraniru basis, or 3 - is the huraniru basis, in claim 6 the akuaporin 4 functional accelerator of statement.
[claim7]
7. The aforementioned chemical compound 2 - phenyl sulfonic amide - 3 - in the claim 6 which is benzyl oxy pyrimidine or 7 the akuaporin 4 functional accelerator of statement.
[claim8]
8. Either of the claim 6-8 the medicine composition for the nervous disease which features that inside the akuaporin 4 functional accelerator of statement, and the carrier and the diluent which can be allowed pharmacy at least each of them is included in one section.
[claim9]
9. In each case the aforementioned nervous disease is chosen from the Alzheimer's disease, the brain blockage and the group which consists of the encephaloma it is one, in claim 9 the medicine composition for the nervous disease of statement.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIIGATA UNIVERSITY
  • 発明者(英語)
  • NAKADA TSUTOMU
  • HUBER VINCENT
  • IGARASHI HIRONAKA
  • SUZUKI YUJI
  • KWEE INGRID
国際特許分類(IPC)
指定国 (WO2017150704)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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