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CURCUMIN-BORON COMPLEX AND PHARMACEUTICAL CONTAINING SAME NEW

外国特許コード F170009274
整理番号 E112P09WO
掲載日 2017年10月31日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2017JP011232
国際公開番号 WO 2017164172
国際出願日 平成29年3月21日(2017.3.21)
国際公開日 平成29年9月28日(2017.9.28)
優先権データ
  • 特願2016-056615 (2016.3.22) JP
発明の名称 (英語) CURCUMIN-BORON COMPLEX AND PHARMACEUTICAL CONTAINING SAME NEW
発明の概要(英語) Provided are a compound that is bioapplicable and amyloid-selective, and is useful as an amyloid oxidation catalyst applicable not only to aβ peptides but to other amyloids as well, and a preventive/therapeutic agent for amyloid-related diseases using the same. A curcumin-boron complex represented by general formula (1) (wherein: X1 and X2 are identical or different, and represent a halogenoalkyl group or an halogen atom; X3 represents a bromine atom, an iodine atom, or a selenium atom; R1 and R2 are identical or different, and represent a hydrogen atom or an optionally substituted alkyl group; R3 and R4 are identical or different, and represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R1 and R3 or R2 and R4 together may form an optionally substituted alkylene group or alkenylene group; R5 and R6 are identical or different, and represent a hydrogen atom or an optionally substituted alkyl group; R7 and R8 are identical or different, and represent a hydrogen atom, a halogen atom, an alkoxy group, or an optionally substituted alkyl group, or R5 and R7 or R6 and R8 together may form an optionally substituted alkylene group or alkenylene group; and m and n represent integers from 1 to 3), or a salt thereof.
特許請求の範囲(英語) [claim1]
1. The next general formula (1)
(In formula, X (1) and X as for (2), equality or differing, showing the halogeno alkyl group or the halogen atom;
X as for (3), showing bromine atom, iodic atom or selenium atom;
R (1) and R as for (2), equality or differing, showing the alkyl group which is possible to have possessed the hydrogen atom or the substituent;
R (3) and R (4), equality or differing, the hydrogen atom and the halogen atom, shows the alkyl group which is possible to have possessed alkoxy group or the substituent, or to be possible to form the alkylene basis or the arukeniren basis where R (1) and R (3), or R (2) and R (4) becomes simultaneous, is possible to have possessed the substituent;
R (5) and R as for (6), equality or differing, showing the alkyl group which is possible to have possessed the hydrogen atom or the substituent;
R (7) and R (8), equality or differing, the hydrogen atom and the halogen atom, showing the alkyl group which is possible to have possessed alkoxy group or the substituent, or to be possible R (5) and R (7), or R (6) and R (8) becoming simultaneous, to form the alkylene basis or the arukeniren basis which is possible to have possessed the substituent;
m and n shows the integer of the 1-3)
So the curcumine boron complex or that salt which is displayed.
[claim2]
2. X (1) is the halogeno alkyl group, X the curcumine boron complex or that salt of the claim 1 statement where (2) is the halogen atom.
[claim3]
3. M and n 1 the claim the curcumine boron complex or that salt of 1 which is or 2 statements.
[claim4]
4. R (1), R (2), R (3), R (4), R (5), R (6), R (7) and R (8) the alkyl group which is possible to have possessed the substituent which shows, the karubokishi basis, sulfonate group and the hydroxy basis, the amino group, - CO-, - either of the claim 1-3 which is the alkyl group which is possible to have possessed the substituent of 1 kinds or more which are chosen from the CONH- BI triazole basis in 1 sections the curcumine boron complex or that salt of statement.
[claim5]
5. R (1) and R (3), R (2) and R (4), R (5) and R (7), or R (6) and R (8) becoming simultaneous, carbon count of the alkylene basis or the arukeniren basis which is formed 2 or 3 either of the claim 1-4 which is in 1 sections the curcumine boron complex or that salt of statement.
[claim6]
6. Either of the claim 1-5 the medicine which designates the curcumine boron complex or that salt of statement as the active ingredient in 1 sections.
[claim7]
7. The medicine of the claim 6 statement which is the preventive of the disease which the pathogenic amyloid is related or remedy.
[claim8]
8. Either of the claim 1-5 the medicine composition which contains the curcumine boron complex or that salt of statement and the carrier which is allowed pharmacy in 1 sections.
[claim9]
9. Prevention of the disease where the pathogenic amyloid participates or either of the claim 1-5 for remedy production in 1 sections the curcumine boron complex of statement or use of that salt.
[claim10]
10. Either of the claim 1-5 in order it prevents or to remedy the disease where the pathogenic amyloid participates in 1 sections the curcumine boron complex or that salt of statement.
[claim11]
11. Either of the claim 1-5 the method where it prevents or remedies the disease which the pathogenic amyloid which features that the curcumine boron complex of statement or the effective quantity of that salt is prescribed to 1 sections is related.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KANAI MOTOMU
  • SOMA YOHEI
  • NI JIZHI
  • TANIGUCHI ATSUHIKO
国際特許分類(IPC)
指定国 (WO2017164172)
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
参考情報 (研究プロジェクト等) ERATO KANAI Life Science Catalysis AREA
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