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生体防御のメカニズム 遺伝子改変に基づく生体防御システムの解明

研究報告コード R990004221
掲載日 2001年2月6日
  • 審良 静男
  • 大阪大学微生物病研究所
  • 大阪大学微生物病研究所
報告名称 生体防御のメカニズム 遺伝子改変に基づく生体防御システムの解明
報告概要 生体防御に関わる転写因子、シグナル伝達分子、膜レセプター、リガンドの遺伝子欠損マウスを作製することにより、それらの各分子の生体内での役割を調べている。
  • 細胞生理一般
  • 生物学的機能
  • 遺伝子操作
  • 生体防御と免疫系一般
関連発表論文 (1)Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T. and Akira, S. Stat3 activation is responsible for IL-6-dcpendent T cell proliferation through preventing apoptosis: Generation and characterization of T cell-specific Stat3-deficient mice. Journal of Immunology, 161, 4652-4660, 1998.
(2)Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K. and Akira, S. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity, 8, 383-390, 1998.
(3)Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K. and Akira, S. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated signalling. Immunity, 9, 143-150, 1998.
(4)Yoshimoto, T., Takeda, K., Tanaka, T., Okusu, K., Kashiwamura, S.-I., Okamura, H., Akira, S. and Nakanishi, K. IL-12 up-regulates IL-18R expression on T cells, Th1 cells and B cells: synergism with IL-18 for IFN-γ production. The Journal of Immunology, 161, 3400-3407, 1998.
(5)Matsumoto, M., Sakao, Y. and Akira, S. Inducible expression of nuclear factor IL-6 increases endogenouse gene expression of macrophage inflammatory-1 α, osteopontin, and CD14 in a monocytic leukemia cell line. International Immunology, 10 (12), 1825-1835, 1998.
(6)Akaishi, H., Takeda, K., Kaisho, T., Shineha, R., Satomi, S., Takeda, J. and Akira, S. Defective IL-2-mediated IL-2 receptor a chain expression in Stat3-deficient T lymphocytes. International Immunology, 10, 1747-1751, 1998.
(7)Sanjo, H., Kawai, T. and Akira, S. DRAKs, novel serine/threonine kinases related to DAP kinase that trigger apoptosis. The Journal of Biological Chemistry, 273, 29066-29071, 1998.
(8)Tanaka, T., Tsujimura, T., Takeda, K., Sugita, A., Maekawa, A., Terada, N., Yoshida, N. and Akira, S. Targeted disruption of ATF4 discloses its essential role in formation of eye lens secondary fibers. Genes to Cell, 3, 801-810, 1998.
(9)Sakao, Y., Takeda, K., Tsutsui, H., Kaisho, T., Nomura, F, Okamura, H., Nakanishi, K. and Akira, S. IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock. International Immunology, 11 (3), 471-480, 1999.
(10)Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, M., Takeda, K. and Akira, S. TLR4-deficient mice are hyporesponsive to LPS: evidence for TLR4 as the Lps gene product. The Journal of Immunology. 162 (7), 3749-3752, 1999.
(11)Takeda, K., Clausen. B. E., Kaisho, T., Tsujimura, T., Terada, N., Foerster, I. and Akira, S. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity, 10, 39-49, 1999.
(12)Kawai, T., Sanjo, H. and Akira, S. Duet is a novel serine/threonine kinases with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Gene, 227, 249-255, 1999.
(13)Hoshino, K., Tsutsui, H., Kawai, T., Takeda, K., Nakanishi, K., Takeda, M. and Akira, S. Generation of IL-18 receptor-deficient mice: evidence for IL-1Rrp as an essential IL-18 binding receptor. The Journal of Immunology, 162, 5041-5044, 1999.
(14)Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N. and Akira, S. Limb and skin abnormalities in mice lacking IKK α. Science, 284, 313-316, 1999.
  • 戦略的基礎研究推進事業、研究領域「生体防御のメカニズム」研究代表者 審良 静男(大阪大学微生物病研究所)/科学技術振興事業団
  • 審良 静男. 生体防御のメカニズム 遺伝子改変に基づく生体防御システムの解明. 戦略的基礎研究推進事業 平成10年度 研究年報,1999. p.131 - 135.