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生体防御のメカニズム 普遍的な生体防御機構としてのストレス応答

研究報告コード R990004227
掲載日 2001年2月6日
  • 永田 和宏
  • 京都大学再生医科学研究所
  • 京都大学再生医科学研究所
報告名称 生体防御のメカニズム 普遍的な生体防御機構としてのストレス応答
報告概要 ストレス応答による生体防御戦略を解明するため、二つの大きな柱を立てている。
  • 生物学的機能
  • 遺伝子の構造と化学
  • 生体防御と免疫系一般
  • 細胞生理一般
関連発表論文 (1)M. TANABE, Y. KAWAZOE, S. TAKEDA, R.I. MORIMOTO, K. NAGATA & A. NAKAI Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. EMBO J. 17(6): 1750-1758 (1998)
(2)I. YAMAMURA, H. HIRATA, N. HOSOKAWA & K. NAGATA: Transcriptional activation of the mouse HSP47 gene in mouse osteoblast MC3T3-E1 cells by TGF-b1. Biochemical and Biophysical Research Communications. 244:68-74 (1998)
(3)Y. KAWAZOE, A. NAKAI, M. TANABE & K. NAGATA: Proteasome inhibition leads to the activation of all members of the heat-shock-factor family. European Journal of Biochemistry. 255:356-362 (1998)
(4)H. MASUDA, N. HOSOKAWA & K. NAGATA: Expression and localization of collagen-binding stress protein HSP47 in mouse embryo development: Comparison with types I and II collagen. Cell Stress & Chaperones. 3(4):256-264 (1998)
(5)N. HOSOKAWA, M. SATOH, C. HOHENADLE, K. KUHN & K. NAGATA:HSP47, a collagen-specific molecular chaperone, delays the secretion of type III procollagen transfected in human embryonic kidney cell line 293:A possible role for HSP47 in collagen modification.J. Biochem. 124(3):654-662(1998)
(6)K. NAGATA, T. KOIDE, H. HIRATA, N. NAGAI, M. SATOH, N. HOSOKAWA: Role of Molecular Chaperone HSP47 in the Synthesis and Secretion of Procollagens. THE 1998 TANIGUCHI INTERNATIONAL SYMPOSIUM “From Molecules to Man: Frontiers in Cell Biology”.
(7)M. SUNAMOTO, K. KUZE, H. TSUJI, N. OHISHI, K. YAGI, K. NAGATA, T. KITA & T. DOI:Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress collagen accumulation in experimental glomerulonephritis. Lab. Invest. 78(8):967-972(1998)
(8)T. KOIDE & K. NAGATA:HSP47, A Molecular Chaperone which Interacts with Procollagens in the Endoplasmic Reticulum. Connective Tissue. 30(4):307-314(1998)
(9)J. NISHIZAWA & K. NAGATA: Regulation of heat shock transcription factors by hypoxia or ischemia/reperfusion in the heart and brain. Handbook of Experimental Pharmacology Stress Proteins Volume 136 (Ed. Latchman.D.S.) Springer-Verlag 1999., pp.201-224.
(10)N. NAGAI, T. YORIHUZI, N. HOSOKAWA & K. NAGATA: The human genome has a functional hsp47 gene (CBP2) and pseudogene (pshsp47). Gene. 227(2):241-248 (1999)
(11)J. NISHIZAWA, A. NAKAI, K. MATSUDA, T. BAN & K. NAGATA: Reactive Oxygen Species Play an Important Role in the Activation of Haet Shock Factor 1 in Ischemia-Reperfused Heart. Circulation. 99(7):934-941(1999)
(12)The mammalian HSF4 gene generates both an activator and a repressor ofheat shock genes by alternative splicing.M. TANABE, N. SASAI, K. NAGATA, X-D. LIU, P. C. C. LIU, D. J. THIELE & A.NAKAI.J. Biol. Chem. 274(39):27845-27856 (1999)
(13)Substrate recognition of collagen-specific molecular chaperone HSP47:Structural requirements and binding regulation.T. KOIDE, S. ASADA & K. NAGATAJ. Biol. Chem. 274(49):34523-34526 (1999)
(14)Separate cis-acting DNA elements control cell type- and tissue-specificexpression of collagen-binding molecular chaperone HSP47.H. HIRATA, I. YAMAMURA, K. YASUDA, A. KOBAYASHI, H. TADA, M. SUZUKI, K.HIRAYOSHI, N. HOSOKAWA & K. NAGATAJ. Biol. Chem. 274(50):35703-35710 (1999)
(15)Effect of HSP47 on prolyl 4-hydroxylation of collagen model peptides.S. ASADA, T. KOIDE, H. YASUI & K. NAGATACell Struct. Funct. 24(4):187-196 (1999)
(16) HSF3 is a major heat shock responsive factor during chicken embryonicdevelopment.Y. KAWAZOE, M. TANABE, N. SASAI, K. NAGATA & A. NAKAIEur. J. Biochem. 265(2):688-697 (1999)
(17)Enhancement of secretion of human procollagen I in mouseHSP47-expressing insect cells.M. TOMITA, K. YOSHIZATO, K. NAGATA & T. KITAJIMAJ. Biochem. 126(6):1118-1126 (1999)
(18)Procollagen binding to both prolyl 4-hydroxylase/protein disu\lfideisomerase and HSP47 within the endoplasmic reticulum in the absence ofascorbate.N. HOSOKAWA & K. NAGATAFEBS. Letters. 466(1):19-25 (2000)
(19)Interaction of Collagen-specific Molecular Chaperone HSP47 withCollagen-model PeptidesT. KOIDE,S. ASADA & K. NAGATAPeptide Science1999 (Ed.N. Fujii)The Japanese Peptide Society,pp.17-20(2000)
(20)Ischemia/reperfusion inlury and heat shock proteins.J. NISHIZAWA & K. NAGATA" Stress proteins in myocardial protection" Landes Bioscience.(2000) in press.
(21)Dynamics and regulation of the stress response: Meeting report on stressresponse and molecular chaperones at Kyoto.M. YOSHIDA, T. ENDO, K. ITO, N. HOSOKAWA & K.NAGATACell Stress & Chaperones. 4(1):66-74 (1999)
  • 戦略的基礎研究推進事業、研究領域「生体防御のメカニズム」研究代表者 永田 和宏(京都大学再生医科学研究所)/科学技術振興事業団
  • 永田 和宏. 生体防御のメカニズム 普遍的な生体防御機構としてのストレス応答. 戦略的基礎研究推進事業 平成10年度 研究年報,1999. p.158 - 161.