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NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF

Foreign code F100002250
File No. F100002250
Posted date 2010年8月31日
Country 世界知的所有権機関(WIPO)
International application number 2008JP066384
International publication number WO 2009/035020
Date of international filing 平成20年9月11日(2008.9.11)
Date of international publication 平成21年3月19日(2009.3.19)
Priority data
  • 特願2007-235933 (2007.9.11) JP
Title NOVEL DIHYDRONAPHTHALENE COMPOUND AND USE THEREOF
Abstract Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent. (In the formula, two -(CH2)l-N(R1)(R2) groups represent a same substituent; R1 and R2 each represents a hydrogen atom, or a same or different alkyl group; or alternatively, R1 and R2 may combine together to form a monocyclic heterocyclic ring with a nitrogen atom having them or additionally together with one or more atoms selected from an oxygen atom, a sulfur atom and a nitrogen atom; R3, R4 and R5 each represents one or more substituents selected from a hydrogen atom, an alkyl group, an acyl group, an alicyclic group, an aromatic group, a halogen atom, an acyloxy group, a cyano group and a nitro group; l represents an integer of 2-5; n represents an integer of 1-4; m represents an integer of 1-5; and q represents an integer of 1-3.)
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • Tokyo University Of Science Educational Foundation Administrative Organization
  • Inventor
  • Shiina, Isamu
IPC(International Patent Classification)
Specified countries AE AG AL AM AO AT AU AZ BA BB BE BF BG BH BJ BR BW BY BZ CA CF CG CH CI CM CN CO CR CU CY CZ DE DK DM DO DZ EC EE EG ES FI FR GA GB GD GE GH GM GN GQ GR GT GW HN HR HU ID IE IL IN IS IT JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LV LY MA MC MD ME MG MK ML MN MR MT MW MX MY MZ NA NE NG NI NL NO NZ OM PG PH PL PT RO RS RU SC SD SE SG SI SK SL SM SN ST SV SY SZ TD TG TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
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