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CELL COMPETITION INHIBITOR

Foreign code F200010240
File No. (S2019-0363-N0,S2019-0367-N0)
Posted date 2020年10月30日
Country 世界知的所有権機関(WIPO)
International application number 2020JP014715
International publication number WO2020196926
Date of international filing 令和2年3月30日(2020.3.30)
Date of international publication 令和2年10月1日(2020.10.1)
Priority data
  • 特願2019-063594 (2019.3.28) JP
  • 特願2019-069777 (2019.4.1) JP
Title CELL COMPETITION INHIBITOR
Abstract The present invention provides a cell competition inhibitor comprising an agonist antibody, which is directed against a protein containing the α3 domain of MHC class Ia or LILRB3, or a substance which inhibits the binding of LILRB3 to MHC class Ia.
Outline of related art and contending technology BACKGROUND ART
Cell competition was originally discovered in Drosophila in 1975 years and studied by (Non-Patent Document 1) and Drosophila researcher. Although it has not been clarified recently whether similar competition phenomena exist in mammalian cells, the present inventors have reported in the world that cell competition occurs in mammals for the first time in 2009 years, It is now clear that cell competition is necessary and universal for maintaining the homeostasis of cellular society. In addition, recent studies have accumulated knowledge on how cells that become sepsis in cell competition are excluded from tissue, and the molecular mechanism thereof.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • WASEDA UNIVERSITY
  • Inventor
  • MARUYAMA, Takeshi
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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