Cyclobutyl purine derivative, angiogenesis promoting agent, lumen formation promoting agent, neurocyte growth promoting agent, and drug

Foreign code	F120006249
File No.	S2009-0108-N0
Posted date	2012年2月17日
Country	カナダ
Application number	2744857
Gazette No.	2744857
Gazette No.	2744857
Date of filing	平成21年11月27日(2009.11.27)
Gazette Date	平成22年6月3日(2010.6.3)
Gazette Date	平成26年2月18日(2014.2.18)
International application number	JP2009070062
International publication number	WO2010061931
Date of international filing	平成21年11月27日(2009.11.27)
Date of international publication	平成22年6月3日(2010.6.3)
Priority data	特願2008-303239 (2008.11.27) JP 2009JP070062 (2009.11.27) WO
Title	Cyclobutyl purine derivative, angiogenesis promoting agent, lumen formation promoting agent, neurocyte growth promoting agent, and drug
Abstract	The application relates to a compound that has at least one selected from the group consisting of cell growth promoting activity, angiogenesis promoting activity, lumenization promoting activity, cell migration promoting activity, and neurocyte growth promoting activity; is chemically a stable low-molecular-weight substance; has a high absorption rate because of the low molecular weight; and can be supplied inexpensively and with stability. This cyclobutyl purine derivative, tautomers and stereoisomers thereof, and salts and solvates of the same are cyclobutyl purine derivatives, tautomers or stereoisorners thereof, and salts and solvates of the same represented by the following general formula (1): (see formula 1) The application also relates to a promoting agent having a cyclobutyl purine derivative of the general formula (1'), a tautomer, or stereoisomer thereof, or a salt, solvate, or hydrate thereof. (see formula 1')
Applicant	KAGAWA UNIVERSITY
Inventor	TSUKAMOTO IKUKO KONISHI RYOJI TOKUDA MASAAKI KUBOTA YASUO MARUYAMA TOKUMI KOSAKA HIROAKI IGARASHI JUNSUKE
IPC(International Patent Classification)	C07D 473/34      ６位に結合するもの，例．アデニン A61K  31/52      プリン，例．アデニン A61P   9/00      循環器系疾患の治療剤 A61P   9/10      虚血，アテローム性動脈硬化症の治療のためのもの，例．抗アンギナ，冠状動脈拡張剤，心筋梗塞，網膜症，脳血流障害，腎臓細動脈硬 A61P  17/02      傷，潰瘍，火傷，傷跡，ケロイドのようなものの治療のためのもの A61P  25/00      神経系疾患の治療薬 A61P  25/28      中枢神経変性疾患治療剤，例．脳機能改善剤，認識増強剤，アルツハイマー病その他の痴呆症の治療剤 C07D 473/40      ２位または６位に直接結合するハロゲン原子または過ハロゲノ―アルキル基を有するもの