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PROMOTOR FOR PERMEATION INTO CELL LAYER, COMPOSITION FOR FACILITATING DRUG AGENT ABSORPTION, AND PHARMACEUTICAL COMPOSITION

Foreign code F200010255
File No. (S2019-0227-N0)
Posted date 2020年11月5日
Country 世界知的所有権機関(WIPO)
International application number 2020JP012446
International publication number WO2020196315
Date of international filing 令和2年3月19日(2020.3.19)
Date of international publication 令和2年10月1日(2020.10.1)
Priority data
  • 特願2019-057323 (2019.3.25) JP
Title PROMOTOR FOR PERMEATION INTO CELL LAYER, COMPOSITION FOR FACILITATING DRUG AGENT ABSORPTION, AND PHARMACEUTICAL COMPOSITION
Abstract Provided is a technique for promoting permeation of a substance into a cell layer. Provided are: a promotor for permeation into a cell layer, constituted of a compound represented by general formula (1); a composition for facilitating drug agent absorption, containing said promotor for permeation into a cell layer and configured to facilitate drug agent absorption into a living body; and a pharmaceutical composition containing said promotor for permeation into a cell layer, and further containing a drug agent to be absorbed by a living body.
Outline of related art and contending technology BACKGROUND ART
In a cell layer forming epithelial tissue or the like, a gap between adjacent cells is sealed by a cell adhesion structure such as a tight junction (TJ: Tight Junction) or the like to fulfill a barrier function against foreign matter. Therefore, the permeability of the intercellular pathway through the intercellular pathway is very limited to maintain the homeostasis of the living body. There is a concept of a drug delivery system (DDS: Drug Delivery System) in which the cell adhesion structure is primarily relaxed to allow a desired substance to permeate through the intercellular pathway, thereby enhancing absorption of a drug or the like into a living body. Some biopharmaceuticals and candidates thereof which are actively developed, such as peptides, proteins, antibodies, vaccines, nucleic acids, etc., have low bioavailability, The development of techniques is desired because the range of applicability of such drugs is widened and the improvement of Quality of Life in a patient is also achieved by non-invasive administration methods such as oral, transdermal, nasal, pulmonary, transmucosal or the like instead of injection administration.
On the other hand, the following Non-Patent Document 6 reports cyclic lipopeptides as antibacterial substances derived from Pseudomonas bacteria.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • UNIVERSITY OF TSUKUBA
  • TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES
  • Inventor
  • USUI Takeo
  • NAGUMO Yoko
  • MUKAIYAMA Minagi
  • HAYASHI Yoshio
  • TANIGUCHI Atsuhiko
  • UCHIYAMA Chihiro
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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