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METHOD FOR PRODUCING GELATINOUS COMPOSITION, AND GELATINOUS COMPOSITION

Foreign code F210010303
File No. (S2019-0508-N0)
Posted date 2021年1月29日
Country 世界知的所有権機関(WIPO)
International application number 2020JP025280
International publication number WO 2020262625
Date of international filing 令和2年6月26日(2020.6.26)
Date of international publication 令和2年12月30日(2020.12.30)
Priority data
  • 特願2019-119814 (2019.6.27) JP
Title METHOD FOR PRODUCING GELATINOUS COMPOSITION, AND GELATINOUS COMPOSITION
Abstract Provided is a method for producing a gelatinous composition, the method including: a step for mixing lecithin that has been dissolved or dispersed in water and an organic compound (excluding lecithin) having a molecular weight of 500 or more that has been dissolved or dispersed in water to obtain a mixed liquid containing the lecithin and the organic compound; a step for freeze-drying or heat-drying the mixed liquid to obtain a solid mixture containing the lecithin and the organic compound; and a step for mixing the solid mixture, an oil component and a polar liquid to obtain a gelatinous composition. Also provided is a gelatinous composition produced using the production method.
Outline of related art and contending technology BACKGROUND ART
Because protein formulations are poorly absorbed from the gastrointestinal mucosa upon oral administration and degrade before being absorbed, most of the formulations have been developed as injectables that do not undergo first-pass effects. However, injectables also have many disadvantages such as being invasive, requiring the technique of a medicator, requiring sterile preparation, and the like.
Routes of administration that do not undergo first-pass effects include transdermal administration. Transdermal preparations have advantages such as simple administration methods, easy maintenance of blood levels, simple interruption of administration, and direct confirmation of medication compliance. However, the keratinous layer of the outermost layer of the skin is a strong barrier, and a water-soluble polymer having a molecular weight of 500 or greater is difficult to penetrate the skin. Therefore, preparations containing water-soluble polymers such as protein preparations cannot usually be administered as transdermal preparations.
Physical promotion methods such as microneedle methods and iontophoresis, nanoparticles, liposomes, surfactant vesicles, microemulsions, and the like have been investigated as methods for enhancing migration of drugs to the skin. Microneedle approach is a method of delivering drugs directly into the skin with fine needles, but is not painful compared to injections, but does not change in needle passage through the skin, which has problems with actual use, such as assurance of sterility. In addition, iontophoresis is a method of promoting absorption of drugs from the skin using electrical energy, but requires specialized devices and is suspected of effectiveness in polymers. In the method using nanoparticles, only appendages such as hair follicles and sweat glands are targeted because the nanoparticles are large to penetrate the stratum corneum. Liposomes have limited formulation in which it is difficult to efficiently and stably encapsulate the drug and can change shape so that it permeates between corner layers. Surfactant vesicles and microemulsions leave safety issues when the surfactant concentration is high or alcohol is needed.
On the other hand, gel-like formulations are widely used in various fields such as cosmetics, pharmaceuticals, foods, paints, inks, lubricants, and the like. There are various methods for preparing gel-like preparations, but the preparation of gel-like preparations by reverse string-like micelles has also been reported (NpL 1). A reversed string-like micelle is a type of self-assembly formed by a surfactant, and is known to induce gelation in order to form a network structure in oil.
The present inventors have found that in the past, lecithin/sucrose fatty acid ester (Patent Document 1), lecithin/saccharide (Patent Document 2), lecithin/urea (Patent Document 3), lecithin/polyglycerol (Patent Document 4); Gel-like compositions by reverse string-like micelles of lecithin/ascorbic acid or a derivative thereof (Patent Document 5) and lecithin/aliphatic carboxylic acid (Patent Document 6) have been developed. In addition, (Non-Patent Document 2) reports attempts to percutaneously absorb hydrophobic low molecules using gel-like compositions by reverse string-like micelles. In addition, the present inventors reported (Patent Document 7) a gel-like composition with enhanced skin migration properties of a water-soluble polymer having a molecular weight of 500 or greater by using reverse string-like micelles.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NIHON UNIVERSITY
  • Inventor
  • HASHIZAKI Kaname
  • FUJII Makiko
  • TAGUCHI Hiroyuki
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL ST SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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