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COLLAGEN FUSION PROTEIN AND DRUG SCREENING METHOD USING SAME 新技術説明会

Foreign code F160008899
File No. (S2015-0733-N0)
Posted date 2016年11月11日
Country 世界知的所有権機関(WIPO)
International application number 2016JP059066
International publication number WO 2016152882
Date of international filing 平成28年3月22日(2016.3.22)
Date of international publication 平成28年9月29日(2016.9.29)
Priority data
  • 特願2015-057688 (2015.3.20) JP
Title COLLAGEN FUSION PROTEIN AND DRUG SCREENING METHOD USING SAME 新技術説明会
Abstract The purpose of the present invention is to construct a system whereby secretion of procollagen from an animal cells can be detected. This purpose can be achieved by a fusion protein of a fluorescent protein or luminescent protein and a collagen-related protein which is a collagen protein, a procollagen protein, a preprocollagen protein having a repeating amino acid sequence of Gly-Xaa-Yaa (where Gly represents glycine and Xaa and Yaa represent arbitrary amino acids), or a variant or fragment thereof.
Outline of related art and contending technology BACKGROUND ART
Collagen, protein 30% occupies in the living body, and cell adhesion skeletal support important proteins and have functions such as, for example, human body bone, cartilage, ligament, tendon, cornea, skin, liver, muscle tissue such as the major constituents. Is collagen, fibrous collagen collagen to form fibrils, in a non - fibrillar collagen does not form fibrils present. Fibrous collagen, the polypeptide chains of the collagen triple helical structure is present 3 3 (tropocollagen) gather to form. 3 Is the double helix structure of the topo collagen, by self-assemble, shifted by 1/4 molecular length alignment, (fibrillar collagen) collagen fibrils to form. Further, this collagen fibrils, and merge the many, collagen fibers (collagen fiber bundles) to form. Further, in the corneal stroma and cortical bone, collagen fibers aligned in the same direction to form a two-dimensional layers, each layer 1 this layer is further laminated veneer-like and then a three-dimensional layer that takes the plate structure. This veneer-like three-dimensional layer board structure is collagen, are transparent and have a high strength.
Of such a collagen molecular abnormalities caused by collagen diseases (for example, dermatomyositis, polymyositis) or corneal cloudiness and the like, a method of treatment has not been established in many cases. This is, collagen secretion of an as-yet and the higher-order structure formation processes in the course also, one cause of 1. And the higher-order structure of collagen secretion analysis step of forming the course can be performed if, due to the collagen molecular abnormalities of clarification of the cause of the disease, and in the development of therapeutic thereof also can be used as an effective means.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • TOKYO INSTITUTE OF TECHNOLOGY
  • Inventor
  • TANAKA Toshiaki
  • IKOMA Toshiyuki
  • TANAKA Junzo
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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