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TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS

Foreign code F130007487
File No. 3216
Posted date 2013年7月10日
Country 世界知的所有権機関(WIPO)
International application number 2011JP003059
International publication number WO 2011/152043
Date of international filing 平成23年5月31日(2011.5.31)
Date of international publication 平成23年12月8日(2011.12.8)
Priority data
  • 20100350420P (2010.6.1) US
Title TRANSGENIC REPORTER SYSTEM THAT REVEALS EXPRESSION PROFILES AND REGULATION MECHANISMS OF ALTERNATIVE SPLICING IN MAMMALIAN ORGANISMS
Abstract

An object of the present invention is to develop a new alternative splicing reporter system and to provide a method for detecting alternative splicing patterns in a mammalian multicellular organism more precisely, a method for identifying efficiently substances and gene regions that affect alternative splicing in a mammalian multicellular organism, and the like by utilizing the alternative splicing reporter system. Specifically, the present invention relates to a method for detecting alternative splicing in a mammalian multicellular organism, and a method for identifying substances and gene regions that affect alternative splicing in a mammalian multicellular organism, which use a DNA construct in which at least two different reporter genes are inserted into a specific gene that undergoes alternative splicing, or a combination of DNA constructs (a combination of at least two different DNA constructs) in which DNA construct a reporter gene is inserted into a specific gene that undergoes alternative splicing.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYOTO UNIVERSITY,
  • HAGIWARA, MASATOSHI,
  • TAKEUCHI, AKIHIDE
  • Inventor
  • HAGIWARA, MASATOSHI,
  • TAKEUCHI, AKIHIDE
IPC(International Patent Classification)
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