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EXTRACT DERIVED FROM GRAPE RACHIS

Foreign code F130007620
File No. L11008PCT
Posted date 2013年9月5日
Country 世界知的所有権機関(WIPO)
International application number 2012JP080892
International publication number WO 2013081046
Date of international filing 平成24年11月29日(2012.11.29)
Date of international publication 平成25年6月6日(2013.6.6)
Priority data
  • 特願2011-259694 (2011.11.29) JP
Title EXTRACT DERIVED FROM GRAPE RACHIS
Abstract A compound shown by the general formula (1), and an antitumor agent containing this compound as an active ingredient. (A)n1-(B)n2… (1); where n1 represents any integer of 6-20, n2 represents any integer of 1-20, A is a group shown by the general formula (2), B is a group shown by the general formula (3), R1-1-R1-3 represent -O-sugar or the like, R1-4 represents -catechin or the like, R1-5 represents -H or -OH, and R2 represents -O-sugar or the like.
Outline of related art and contending technology BACKGROUND ART
The grape wine or the like as a raw material of the workpiece during manufacture, grape aperture shavings, intradermal, matched with the color, a large amount of residue . Conventional, only to discard these, processing expensive and, by applying a load to the environment problem. Therefore, in order to make effective use of these residues are, various studies have been made.
For example, in patent document 1, red grape skin, polyphenols extracted from one extract as a main component, can inhibit the growth of human gastric cancer cell has been identified, this induction of apoptosis of gastric cancer cell extracts suggested that can be utilized. In addition, in Patent Document 2, etc. contained in the wine is matched with the catechin (polyphenol) prevention of the onset of symptoms of prostate cancer or prostatic hyperplasia and the purpose of improving the formulation of the agent can be utilized is shown.
Further, in Patent Document 3, phenol compound content of which is increased in order to obtain a wine, a wine brewing method, and the result added to the cooked mash fermentation rachis grape is disclosed, in Patent Document 4, grape draff, pericarp, leaf, extracted from polyphenol contained in the food or drink product which is a kind of resveratrol contained in, the color tone can be held in the food or drink disclosed. Grape residue are also can be said that the method is for effective use, provide a further useful method of use has been desired.
In the present invention, any one of the grape residue, as a raw material a large amount of rachis, hot water, hydrous alcohol, hydrous acetone, hydrophilic solvent or a mixture of lipophilic solvents and amphiphilic solvents by extraction to obtain the extract. Further, as derived from grape rachis compound. Then, grape rachis extracts containing compound derived from the anti-tumor effect, particularly an anti-tumor effect for prostate cancer or metastasis of a tumor by the finding that inhibition action, the new use of the grape residue to provide a method according to the present invention. As described above, in Patent Document 2, and the product can be extracted from grape is matched with the catechin (polyphenol) prevention of the onset of prostate cancer or prostatic hyperplasia such as improvement in symptoms shown can be utilized. However, in that Patent Document 2 is matched with the grapes from the product of catechin (polyphenols) and a method of extracting, also an effect by this formulation is not specifically shown, grape residue sufficiently useful applications of the disclosed method is far from.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • SHINSHU UNIVERSITY
  • ST. COUSAIR CO., LTD.
  • Inventor
  • FUJII, Hiroshi
  • KAWAHARA, Seiichi
  • MAKABE, Hidefumi
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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