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CAPSULE PROTEIN AND MULTIMERIC COMPLEX COMPOSITION THEREOF, AND PHARMACEUTICAL COMPOSITION USING SAME

Foreign code F210010291
File No. (S2019-0482-N0)
Posted date 2021年1月28日
Country 世界知的所有権機関(WIPO)
International application number 2020JP019827
International publication number WO 2020235570
Date of international filing 令和2年5月19日(2020.5.19)
Date of international publication 令和2年11月26日(2020.11.26)
Priority data
  • 特願2019-094819 (2019.5.20) JP
Title CAPSULE PROTEIN AND MULTIMERIC COMPLEX COMPOSITION THEREOF, AND PHARMACEUTICAL COMPOSITION USING SAME
Abstract There has been an idea to pack a pharmaceutical agent in a lipocalin-type prostagladin H synthase having a barrel structure, and seal the pharmaceutical agent in the barrel structure by introducing a disulfide bond between α-helix H2 and E-F loop. However, in some cases the pharmaceutical agent is released through a gap in an opening of the barrel structure. This capsule protein is characterized in that: a cysteine, which is the active center of a human lipocalin-type prostagladin D synthetase, has been substituted with alanine; and at least one amino acid of a β strand D has been substituted with a barrier amino acid. The capsule protein has a barrier amino acid provided to the β strand D constituting the opening of the barrel structure, and as a result, the release of the pharmaceutical agent that has been packed is suppressed.
Outline of related art and contending technology BACKGROUND ART
In DDS, the development of drug carriers is a key technique. Liposomes, microparticles, nano-related substances, drug-polymer conjugates, and the like have been investigated. Among these, polymer micelles have been focused on as favored carriers for the transmission of poorly water-soluble drugs. For example, Patent Document 1) discloses a micelle-forming composition comprising a hydrophobic core surrounded by a hydrophilic shell, wherein the hydrophilic shell comprises PVP (N-vinyl-2-pyrrolidone).
Patent Document 2 discloses lipocalin type prostaglandin d synthase ((hereinafter referred to as "L-PGDS"), which is a biological product. a capsule protein modified with) discloses that the effect of a drug can be exhibited by dissolving a poorly water-soluble drug in water and administering the drug. Because the capsule protein modified with L-PGDS is an organism in vivo, it is not an antigen and is not toxic to humans, so it can be said to be a safe and reliable drug delivery device.
Patent Document 3 discloses a protein in which a capsule protein modified with L-PGDS is labeled to recognize affected cells. For example, it is thought that a capsule protein modified with L-PGDS, which is labeled peptide that specifically binds to cancer cells, collects in affected cancer cells and improves the therapeutic effect.
Patent Document 4 discloses a protein in which 34 th and 92 th tryptophan from the N-terminal of a capsule protein modified with L-PGDS are replaced with cysteine, and a lid made of a disulfide bond that opens and closes in an oxidation-reduction atmosphere is provided. The purpose of the present invention is to enhance the ability to retain the drug by opening and closing disulfide bonds.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • UNIVERSITY PUBLIC CORPORATION OSAKA
  • Inventor
  • INUI Takashi
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL ST SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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