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NOVEL METHOD FOR INDUCING OSTEOGENIC DIFFERENTIATION 新技術説明会

Foreign code F210010452
File No. 5934
Posted date 2021年5月24日
Country 欧州特許庁(EPO)
Application number 18892944
Gazette No. 3730606
Date of filing 平成30年12月18日(2018.12.18)
Gazette Date 令和2年10月28日(2020.10.28)
International application number JP2018046513
International publication number WO2019124348
Date of international filing 平成30年12月18日(2018.12.18)
Date of international publication 令和元年6月27日(2019.6.27)
Priority data
  • 特願2017-243241 (2017.12.19) JP
Title NOVEL METHOD FOR INDUCING OSTEOGENIC DIFFERENTIATION 新技術説明会
Abstract The present invention provides a method for inducing osteogenic differentiation, the method comprising the following steps of: (1) culturing pluripotent stem cells under feeder-free conditions, (2) culturing the cells in a mixed culture medium of an osteogenic induction medium and a pluripotent stem cell medium, the mixed culture medium containing a ROCK inhibitor and a retinoic acid receptor α or β agonist, and (3) culturing the cells in an osteogenic induction medium containing the retinoic acid receptor α or β agonist. The method for inducing osteogenic differentiation according to the present invention is a simple, short-term, highly efficient and highly reproducible one-procedure method for inducing osteogenic differentiation, wherein the method is suitable for bone regeneration therapies, the development of bone metabolic drugs and the development of novel therapies for bone diseases.
  • Applicant
  • Kyoto University
  • Inventor
  • TOGUCHIDA JUNYA
  • KAWAI SHUNSUKE
  • YOSHITOMI HIROYUKI
  • CANTAS ALEV
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