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DRUG DELIVERY COMPOSITION AND PHARMACEUTICAL COMPOSITION

Foreign code F210010302
File No. (S2019-0497-N0)
Posted date 2021年1月29日
Country 世界知的所有権機関(WIPO)
International application number 2020JP018512
International publication number WO 2020255574
Date of international filing 令和2年5月7日(2020.5.7)
Date of international publication 令和2年12月24日(2020.12.24)
Priority data
  • 特願2019-115688 (2019.6.21) JP
Title DRUG DELIVERY COMPOSITION AND PHARMACEUTICAL COMPOSITION
Abstract This drug delivery composition is for the delivery of a drug to the spinal cord; comprises a membrane-permeable peptide and a block copolymer in which a polyethylene glycol segment is linked to a hydrophobic polyester segment; and is administered nasally. This pharmaceutical composition comprises the drug delivery composition and a drug for the treatment of a spinal cord disease and is administered nasally for the treatment of a spinal cord disease.
Outline of related art and contending technology BACKGROUND ART
Drug delivery to the spinal cord via systemic circulating blood by oral or intravenous administration is significantly limited by the blood-brain barrier and blood-cerebrospinal fluid barrier, making it difficult to increase the drug concentration in spinal cord tissue to the therapeutic area. In addition, because a large amount of medicament is administered to increase the treatment area, side effects on peripheral tissues may be exhibited via systemic circulation. Intrathecal administration can selectively deliver drugs to spinal cord tissue, but administration planning is difficult because administration requires techniques, is highly invasive, and bears a large burden on a patient.
On the other hand, drug delivery technology has been developed as a technology for delivering drugs to disease sites. g. Methoxypolyethylene glycol (Methoxy Polyethylene Glycol: MPEG) segments and poly (epsilon-caprolactone) (Poly (epsilon-caprolactone): (Patent Document 1) reports a nucleic acid delivery composition containing a block copolymer consisting of PCL) segments and a peptide comprising a liposoluble group consisting of 10 amino acids including arginine and histidine.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NIHON UNIVERSITY
  • SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION
  • Inventor
  • KANAZAWA Takanori
  • KOSUGE Yasuhiro
  • MIYAGISHI Hiroko
  • SUZUKI Naoto
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL ST SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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