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DIAGNOSTIC METHOD FOR CHRONIC INFLAMMATORY DISEASES USING ANTIBODY AGAINST INHIBITORY CO-STIMULATORY MOLECULES AS MARKER

Foreign code F130007167
File No. S2011-0242-C0
Posted date 2013年2月25日
Country 世界知的所有権機関(WIPO)
International application number 2011JP076507
International publication number WO 2012/086346
Date of international filing 平成23年11月17日(2011.11.17)
Date of international publication 平成24年6月28日(2012.6.28)
Priority data
  • 特願2010-286456 (2010.12.22) JP
Title DIAGNOSTIC METHOD FOR CHRONIC INFLAMMATORY DISEASES USING ANTIBODY AGAINST INHIBITORY CO-STIMULATORY MOLECULES AS MARKER
Abstract

Provided is a diagnostic method for chronic inflammatory diseases, the main condition of which is lymphocyte infiltration. Specifically provided is a diagnostic method which is capable of distinguishing chronic inflammatory diseases, the main condition of which is lymphocyte infiltration, from acute inflammation and inflammatory diseases, the main condition of which is not lymphocyte infiltration, said distinguishment having been impossible by conventional inflammation markers. The diagnostic method is enabled by measuring an antibody against inhibitory co-stimulatory molecules (such as PD-1, BTLA or CTLA-4) expressed in T cells and/or B cells. This diagnostic method enables distinguishment of chronic inflammatory diseases, the main condition of which is lymphocyte infiltration, from acute inflammation and inflammatory diseases, the main condition of which is not lymphocyte infiltration. A remarkable difference can be recognized among diseases that have similar clinical conditions by measuring the antibody, so that distinguishment among such diseases becomes possible.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY,
  • MIYAKE, YASUHIRO,
  • YAMAMOTO, KAZUHIDE,
  • MATSUMOTO, KAZUYUKI
  • Inventor
  • MIYAKE, YASUHIRO,
  • YAMAMOTO, KAZUHIDE,
  • MATSUMOTO, KAZUYUKI
IPC(International Patent Classification)

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