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METHOD FOR PRODUCING MODEL ANIMAL, AND MODEL ANIMAL

Foreign code F130007582
File No. S2011-0908-C0
Posted date 2013年7月24日
Country 世界知的所有権機関(WIPO)
International application number 2012JP065668
International publication number WO 2013/094240
Date of international filing 平成24年6月19日(2012.6.19)
Date of international publication 平成25年6月27日(2013.6.27)
Priority data
  • 特願2011-282413 (2011.12.22) JP
Title METHOD FOR PRODUCING MODEL ANIMAL, AND MODEL ANIMAL
Abstract

Provided are: a method for producing a model animal which has a desired lifetime, and in which a predetermined biological reaction can be induced

and a model animal. According to the present invention, a first individual in which a gene of interest is heterozygously deficient is produced using a first ES cell originated from a non-human mammal. On the other hand, a fragment containing a homologous gene that has homology with the gene of interest is produced. Using a second ES cell that is so adapted that a predetermined region on X-chromosome of the mammal can be substituted, the fragment is introduced into the second ES cell, thereby producing a substituted ES cell in which the predetermined region is substituted by the fragment. Using the substituted ES cell, a second individual is produced. The first individual and the second individual are mated with each other, thereby producing a model animal.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY,
  • OHMURAYA MASAKI,
  • ARAKI KIMI
  • Inventor
  • OHMURAYA MASAKI,
  • ARAKI KIMI
IPC(International Patent Classification)
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