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NON-HUMAN MAMMAL MODEL FOR NORMAL TENSION GLAUCOMA

Foreign code F130007328
File No. S2011-0498-C0
Posted date 2013年4月26日
Country 世界知的所有権機関(WIPO)
International application number 2012JP056627
International publication number WO 2012124752
Date of international filing 平成24年3月15日(2012.3.15)
Date of international publication 平成24年9月20日(2012.9.20)
Priority data
  • 特願2011-057926 (2011.3.16) JP
Title NON-HUMAN MAMMAL MODEL FOR NORMAL TENSION GLAUCOMA
Abstract The present invention provides a genetically modified non-human mammal where a mutation, substituting Asp or Glu for the Ser that is the Cdk5 phosphorylation site of the c-Src protein, has been introduced into the Src gene. Provided thereby is a novel non-human mammal and the like which can be used as a model for normal tension glaucoma.
Outline of related art and contending technology BACKGROUND ART
Glaucoma, optic nerve is damaged for some reason, the field of progressive disease and are damaged, is left as it is, ultimately leading to a high possibility that the blindness.
1 A high intraocular pressure glaucoma is one of glaucoma, the anterior chamber is deteriorated and the excretion of aqueous humor in the eye pressure (intraocular pressure) by the increase in the optic nerve atrophy and is pressed, visual function so that fluid is damaged, a field of view is narrowed disease.
Normal tension glaucoma is, from a height of prevalence, are of particular interest in the recent disease. And about 400 million Japanese glaucoma patients, of which about 3 one-half the normal tension glaucoma patient 2. Is normal tension glaucoma, normal intraocular pressure (in humans usually 10-21mmHg) even though not, finding similar to that of the high intraocular pressure glaucoma (optic nerve atrophy and loss of vision) and exhibits a disease state, specifically, not accompanied by inflammation of the nerve can be (a), (b) lesion is retinal ganglion cell (RGC: retinal ganglion cell) be restrictive, (c) a nervous disorder to proceed over time, the optic papilla (d) characteristic findings have (recessed), (e) maintained in a normal eye pressure, which is characteristic of the such as. Is normal tension glaucoma, slow the progress of the subjective symptom is small, early detection is difficult, also at present, other than to lower eye pressure further, and therapy is not determined.
Normal tension glaucoma model non-human mammal is obtained, useful in the treatment of normal tension glaucoma therapeutic agent for the development of, the establishment of a method for the treatment, and a cause of the disease and also for elucidation of the pathogenesis, expected to be extremely valuable.
Here, as a model mouse normal tension glaucoma, the anterior chamber and the ablation laser exhaust path (non-patent document 1), placing a bead the anterior chamber (non-patent document 2), the vein is solidified so that the discharge of aqueous (non-patent document 3) as, and the like are known. However, any of the model, it is difficult to adjust in intraocular pressure, can be associated with inflammation, can be a contradiction in the pathogenesis, such as a problem.
In addition, GLAST gene were deleted normal tension glaucoma also known model mouse (non-patent document 4, patent document 1). Is GLAST, nerve information possibly because the collecting mechanism known as metabotropic glutamate transporter in.
As normal tension glaucoma model mouse, the progress of a condition including is gradual, actual human normal tension glaucoma in the same manner as of the onset of symptoms similar to mechanism is demanded.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • UNIVERSITY OF YAMANASHI
  • Inventor
  • KASHIWAGI Kenji
  • KATO Goro
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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