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NUCLEAR MAGNETIC RESONANCE DEVICE, AND MICROCRYSTALLINE STRUCTURE ANALYSIS METHOD

Foreign code F200010045
File No. 6235
Posted date May 14, 2020
Country WIPO
International application number 2019JP033687
International publication number WO 2020045490
Date of international filing Aug 28, 2019
Date of international publication Mar 5, 2020
Priority data
  • P2018-162723 (Aug 31, 2018) JP
Title NUCLEAR MAGNETIC RESONANCE DEVICE, AND MICROCRYSTALLINE STRUCTURE ANALYSIS METHOD
Abstract The objective of the present invention is to provide a nuclear magnetic resonance device and a microcrystalline structure analysis method with which a nuclear magnetic resonance signal that is effective for crystal structure analysis can be detected, even with a specimen with which said effective nuclear magnetic resonance signal cannot conventionally be detected. A nuclear magnetic resonance device 1 which excites nuclear magnetic resonance by radiating pulsed electromagnetic waves at a sample disposed in a static magnetic field, and detects a nuclear magnetic resonance signal generated by the nuclear magnetic resonance, is provided with: a static magnetic field source 4 which generates the static magnetic field; a transmitting and receiving unit 5 for radiating the electromagnetic waves and detecting the nuclear magnetic resonance signal; a rotating mechanism 10 which causes a sample container 2 in which microcrystals 3 are suspended to rotate at a variable speed, in such a way that the sample container 2 rotates at a variable speed in the static magnetic field in order to apply a time varying magnetic field thereto to three dimensionally orientate the microcrystals; and a control unit 7 for controlling the transmitting and receiving unit 5 to radiate the electromagnetic waves in synchronism with the variable speed rotation of the sample container 2.
Outline of related art and contending technology BACKGROUND ART
, MAS(Magic Angle Spinning) as to analyze a crystal structure of the object using a nuclear magnetic resonance method (NMR device) has been known. The nuclear magnetic resonance apparatus, the sample is inclined in the magic angle with respect to the static magnetic field, for example 5KHz-20KHz is rotated at high speed, during the rotation of the sample irradiated by the electromagnetic wave generated when the nuclear magnetic resonance (NMR; Nuclear Magnetic Resonance) signal is detected, according to the present invention to analyze a crystal structure of the sample (see Patent Document 1). In addition, as to analyze a crystal structure of the object, the sample is suspended in a time-varying magnetic field to the micro-crystal is applied, the three-dimensional orientation ( crystallization) to microcrystalline the result of analysis by X-ray irradiated X-ray structure analysis apparatus has been known (see Patent Document 2).
Scope of claims (In Japanese)[請求項1]
 静磁場内に配置された試料にパルス状の電磁波を照射して核磁気共鳴を励起し、当該核磁気共鳴によって発生する核磁気共鳴信号を検出する核磁気共鳴装置であって、
 前記静磁場を発生させる静磁場源と、
 前記電磁波を照射させるとともに前記核磁気共鳴信号を検出するための発信受信部と、
 前記静磁場内で微結晶を懸濁させた前記試料を変速回転させることで、前記試料に時間的に変動する磁場を印加して前記微結晶を三次元配向させる回転機構と、
 前記試料の変速回転と同期して前記電磁波を照射させるように前記発信受信部を制御する制御部と、を備える核磁気共鳴装置。

[請求項2]
 前記制御部は、前記試料の変速回転と前記電磁波の照射とを同期させるタイミングを調整可能である、請求項1に記載の核磁気共鳴装置。

[請求項3]
 前記回転機構は、前記試料を180×n°(nは任意の自然数)回転させるたびに、その回転を一時的に停止させるものである、請求項1又は2に記載の核磁気共鳴装置。

[請求項4]
 前記回転機構は、前記試料を前記静磁場の磁場方向に対して垂直方向に延びる回転軸回りに変速回転させるものであり、
 前記回転軸を前記磁場方向に対して垂直以外の任意の角度に傾斜させる傾斜機構をさらに備え、
 前記制御部は、前記電磁波を前記試料に照射させる直前に、前記回転軸を前記任意の角度に傾斜させるように前記傾斜機構を制御する、請求項1~3のいずれか1項に記載の核磁気共鳴装置。

[請求項5]
 静磁場内で微結晶を懸濁させた試料を変速回転させることで時間的に変動する磁場を印加して前記微結晶を三次元配向させる工程と、
 前記試料の変速回転と同期して前記試料にパルス状の電磁波を照射して核磁気共鳴を励起し、当該核磁気共鳴によって発生する核磁気共鳴信号を検出する工程と、を含む微結晶構造解析方法。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYOTO UNIVERSITY
  • Inventor
  • KUSUMI, Ryosuke
  • TAKEDA, Kazuyuki
  • KIMURA, Tsunehisa
  • KADOMA, Hiroshi
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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