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SELF-ASSEMBLY FOR ACTIVATING IMMUNITY

外国特許コード F200010048
整理番号 6202
掲載日 2020年5月14日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP033920
国際公開番号 WO 2020045570
国際出願日 令和元年8月29日(2019.8.29)
国際公開日 令和2年3月5日(2020.3.5)
優先権データ
  • 特願2018-161582 (2018.8.30) JP
発明の名称 (英語) SELF-ASSEMBLY FOR ACTIVATING IMMUNITY
発明の概要(英語) Provided are: a novel compound that forms a self-assembly; the self-assembly; production methods for the compound and the self-assembly; and pharmaceutical use of the compound and the self-assembly. The compound is represented by formula (I) [in the formula, Rx represents H or a group represented by formula (II), Ry represents H or a group represented by formula (III), R1, R2, R3, and R4 each independently represent H, C1-6 alkyl, or C1-6 haloalkyl, a wavy line represents a binding site, and n represents an integer of 1-12]. The self-assembly is formed by the composition. The production methods are for the compound and the self-assembly, and the pharmaceutical use are for the compound and the self-assembly.
従来技術、競合技術の概要(英語) BACKGROUND ART
Biological in vivo in the formation of a hierarchical structure, such as self-assembly of molecules spontaneously self-assembled is an important role. For example, DNA, lipid membrane and cytoskeletal fibers and the like are an example of the natural self-assembly. In general, a single compound having a single function of the molecules on the other hand, the self-assembly in accordance with the ambient environment or complex physical and chemical properties of the (non-patent document 1) function. Therefore, the synthesis of the new self-assembly, a biological system to modulate the activity or biological function of a new drug development has been attracting attention as one of techniques.
Immunopotentiators action of the biological activity, age 1920 using the aluminum compound since adjuvant have been developed, a variety of immune activation agent such as diphtheria or influenza infections disease vaccine used. Is immunopotentiators of these, such as Toll-like receptor (TLR) by acting on the pattern recognition receptors of the immune cells are activated and, for example non-methylated CG (CpG-ODN) or synthetic oligonucleotides comprising sequences and the like have been known (Non-Patent Document 2). In this way, natural self-assembly of self-assembly in a manner similar to the structure have been reported that some, most of the peptide and a constituent unit of the self-assembly. Non-peptide synthesis may be an example of a self-assembly of chemical molecules have been known some embodiments, the biological activity of their toxicity and primarily relates to cell death (Non-Patent Document 3-10). Therefore, the biological activity of the new and useful additional synthetic chemical molecule self-assembly has been desired.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • OSAKA UNIVERSITY
  • 発明者(英語)
  • UESUGI, Motonari
  • VU, Hue T.
  • YOSHIDA, Hiroki
  • NODA, Naotaka
  • JIN, Shuyu
  • YAMASAKI, Sho
  • SHIMANE, Toru
  • ISHII, Ken
  • HIOKI, Kou
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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