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COMPOSITION FOR CORNEAL PROTECTION NEW

外国特許コード F200010073
整理番号 5962
掲載日 2020年5月15日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP047749
国際公開番号 WO 2019131720
国際出願日 平成30年12月26日(2018.12.26)
国際公開日 令和元年7月4日(2019.7.4)
優先権データ
  • 特願2017-251839 (2017.12.27) JP
発明の名称 (英語) COMPOSITION FOR CORNEAL PROTECTION NEW
発明の概要(英語) 本発明者らは、特定のタイプのVCP阻害剤が角膜内皮細胞および角膜上皮細胞に対して保護効果を有することを発見した。 結果として、式(I)の化合物またはそのエステル、酸化物、薬学的に許容される塩もしくは溶媒和物を含む角膜保護のための組成物が提供される。 別の実施形態として、前述の化合物を含有する角膜疾患の治療および/または予防のための医薬組成物が提供される。 さらなる実施形態として、化合物を含有する眼灌流用の組成物が提供される。 なおさらなる実施形態として、前記化合物を含有する移植された角膜保存のための組成物が提供される。
従来技術、競合技術の概要(英語) BACKGROUND ART
The cornea, which is one of the tissue comprising the eye. Is the innermost of the cornea and the corneal endothelial cell, has a function of the pump, in order to maintain the transparency of the cornea is essential. Is not capable of splitting the corneal endothelial, once receiving the failure is not recovered. The damaged portion of the endothelial cells around the enlarged area is made up, and the number of cells is too small and cannot maintain the transparency of the cornea, vision is extremely deteriorated.
Corneal endothelial is, such as glaucoma or cataract surgical invasive, rapid increased intraocular pressure, inflammation, trauma, corneal dystrophies impaired by disease such as Balanced fluoride may be. If the condition progresses, the cornea (the corneal endothelial keratoplasty such as cornea transplant or all layers) is reduced by the corneal endothelial cell becomes necessary to compensate for. Can be reproduced or corneal endothelial cells, endothelial cells of the cornea or suppressing a decrease in the effective treatment.
Corneal epithelial cells, the limbus (the cornea and conjunctiva boundary portion) and its stem cell, and the turnover of the day. However, the inflammatory disease such as trauma PFEUM and is fatigued by the stem cells, a sufficient supply of corneal epithelial cells is not performed, a defect in the corneal epithelium to be prolonged. As a result, the transparency becomes difficult to maintain the cornea, conjunctiva of the corneal epithelium and the papermaking machine, vision is reduced. In addition, a failure in the corneal epithelium, often with a strong eye pain. Cornea and corneal epithelial cells and epithelial stem cells in order to suppress the decrease of an anti-inflammatory agent or the like is used, the effect is restrictive.
Cornea transplant surgery at the time of the eye, and the need to protect the cornea. Current, are used at the time of surgery perifusate eye as the eye, retina and cornea endothelial cells in order to protect the cells, the product is added to the glutathione. On the other hand, a donor cornea for corneal transplant is stored, typically, such as Optisol-GS uses corneal preservative solution, at the maximum can be stored not only about 2 weeks.
In this way, to protect the cornea, treating or preventing a disease against the cornea, multifaceted demand.
Inhibiting activity VCP(valosin-containing protein) ATPase certain 4-amino-naphthalene sulfonic acid derivatives (Patent Document 1) is set to-1-, glaucoma, retinitis pigmentosa, age-related macular degeneration, eye diseases such as ischemic diseases of the eye to be effective in the treatment or prophylaxis has been known (JP-2-4, 2 and Non-Patent Document 1). These diseases, the presence of the eye after the damage to the optic nerve and retinal tissue. To the cornea is the effect of these agents are not known.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION
  • THE DOSHISHA
  • 発明者(英語)
  • IKEDA, Hanako
  • KAKIZUKA, Akira
  • KINOSHITA, Shigeru
  • NAKAMURA, Takahiro
  • NAGATA, Maho
  • KOIZUMI, Noriko
  • OKUMURA, Naoki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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