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CELL CYCLE PROGRESSION INHIBITOR

Foreign code F200010078
File No. 5898
Posted date May 15, 2020
Country WIPO
International application number 2019JP007414
International publication number WO 2019167973
Date of international filing Feb 27, 2019
Date of international publication Sep 6, 2019
Priority data
  • P2018-036296 (Mar 1, 2018) JP
Title CELL CYCLE PROGRESSION INHIBITOR
Abstract The present invention provides a cell cycle progression inhibitor, a cytostatic agent, and an anticancer agent. The cell cycle progression inhibitor, the cytostatic agent, and the anticancer agent each contains a Hes1 protein-PHB2 protein binding enhancer.
Outline of related art and contending technology BACKGROUND ART
Cancers are the top causes of death worldwide, and it is known that, among the cancers, pancreatic cancer is difficult to be detected early, progresses quickly, and has bad prognosis. Therefore, more effective anticancer agents have been desired to be developed.
An agent that inhibits cell cycle progression using, as a target, a signal transduction pathway that relates to, for example, cell growth has been reported as an anticancer agent. For example, a certain type of γ secretase inhibitor causes the stop of cell cycle in G0/G1 phase and accordingly exerts an anticancer effect.
It is known that Hes1 protein is a transcription factor positioned on the downstream side of Notch signal transduction pathway and is involved in, for instance, self biogenesis of pancreas precursor cell.
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYOTO UNIVERSITY
  • Inventor
  • UESUGI, Motonari
  • PERRON, Amelie
  • KODAMA, Yuzo
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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