CELL CYCLE PROGRESSION INHIBITOR
|Posted date||May 15, 2020|
|International application number||2019JP007414|
|International publication number||WO 2019167973|
|Date of international filing||Feb 27, 2019|
|Date of international publication||Sep 6, 2019|
|Title||CELL CYCLE PROGRESSION INHIBITOR|
|Abstract||The present invention provides a cell cycle progression inhibitor, a cytostatic agent, and an anticancer agent. The cell cycle progression inhibitor, the cytostatic agent, and the anticancer agent each contains a Hes1 protein-PHB2 protein binding enhancer.|
|Outline of related art and contending technology||
Cancers are the top causes of death worldwide, and it is known that, among the cancers, pancreatic cancer is difficult to be detected early, progresses quickly, and has bad prognosis. Therefore, more effective anticancer agents have been desired to be developed.
An agent that inhibits cell cycle progression using, as a target, a signal transduction pathway that relates to, for example, cell growth has been reported as an anticancer agent. For example, a certain type of γ secretase inhibitor causes the stop of cell cycle in G0/G1 phase and accordingly exerts an anticancer effect.
It is known that Hes1 protein is a transcription factor positioned on the downstream side of Notch signal transduction pathway and is involved in, for instance, self biogenesis of pancreas precursor cell.
|IPC(International Patent Classification)|
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
Contact Information for " CELL CYCLE PROGRESSION INHIBITOR "
- Kyoto University Office of Society-Academia Collaboration for Innovation
- URL: https://www.saci.kyoto-u.ac.jp/
- Address: 36-1, Yoshida-honmachi, Sakyo-ku, Kyoto-shi, Kyoto, JAPAN , 606-8501
- Fax: +81-75-753-7591