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METHOD FOR INTRODUCING POLYNUCLEOTIDE TO MALE GERM CELL OR SERTOLI CELL NEW

外国特許コード F200010091
整理番号 5711
掲載日 2020年5月15日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2018JP017650
国際公開番号 WO 2018207736
国際出願日 平成30年5月7日(2018.5.7)
国際公開日 平成30年11月15日(2018.11.15)
優先権データ
  • 特願2017-092384 (2017.5.8) JP
発明の名称 (英語) METHOD FOR INTRODUCING POLYNUCLEOTIDE TO MALE GERM CELL OR SERTOLI CELL NEW
発明の概要(英語) The present disclosure relates to a method for introducing a polynucleotide to a male germ cell or Sertoli cell, the method including injection of an adeno-associated virus vector containing the polynucleotide to a testicle of a vertebrate.
従来技術、競合技術の概要(英語) BACKGROUND ART
Stem cells sperm, having the ability to self-replicate only male germ cells, the cells of transduction, the preparation of the genetically modified animal is a possibility that the efficiency can be greatly improved. Spermatogenesis field in the tube definition, Sertoli cell formed by the barrier film on the side of the base section of the testis blood lumen of the section and not, undifferentiated stem cells sperm male germ cells, the base film side of the compartment are protected by the present. To stem cells sperm with a retroviral vector of the gene is reported, the stem cells sperm in order to reach the vector, the blood is not formed across the testes such tubules into young vector is required. Such that the microscopic to the juvenile a very high definition tube into the required technology, moreover, can be implanted in a restricted time.
Sertoli cells, sperm cells that support the formation, to male infertility are implicated. Lentivivus or adenoviral vector definition microscopic tube Sertoli cell by injecting a gene to have been reported, the germline gene pmBCmCNluci insertion mutation introduced into a cell may result, in addition, the adenoviral vector induces inflammatory response is a problem.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • 発明者(英語)
  • SHINOHARA, Takashi
  • WATANABE, Satoshi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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