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RADIOACTIVE HALOGEN-LABELED PYRIDO[1,2-A]BENZIMIDAZOLE DERIVATIVE COMPOUND

外国特許コード F200010097
整理番号 5143
掲載日 2020年5月18日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP055357
国際公開番号 WO 2017029820
国際出願日 平成28年2月24日(2016.2.24)
国際公開日 平成29年2月23日(2017.2.23)
優先権データ
  • 特願2015-161472 (2015.8.19) JP
発明の名称 (英語) RADIOACTIVE HALOGEN-LABELED PYRIDO[1,2-A]BENZIMIDAZOLE DERIVATIVE COMPOUND
発明の概要(英語) The present invention relates to: a radioactive halogen-labeled pyrido[1,2-a]benzimidazole derivative compound represented by a specific general formula or a salt thereof; or a radioactive medicine comprising the compound or the salt.
従来技術、競合技術の概要(英語) BACKGROUND ART
(AD) in the brain is Alzheimer's disease, amyloid β protein (A β) as a main component (SP) and neuritic plaques, tau protein as a main component accumulation of neurofibrillary tangles (NFT) found. Compared to the accumulation of NFT SP exhibits a high correlation with clinical symptoms, recently, targeted protein with a nuclear medicine diagnostic imaging probes for the development of radioactive molecules has attracted attention.
For example, in patent document 1, have an affinity for a protein with a radioactive iodine rhodanine and thiohydantoin derivatives described in a labeled compound.
In addition, the patent document 2-4, binding to both A β and protein with a compound having described. Specifically, the patent document 2, styryl benzimidazole mother nucleus and radioactive iodine labeled compound, in Patent Document 3, all of which benzimidazole pyrimidine, is Patent Document 4, a mother nucleus styryl benzothiazole and radioactive iodine labeled compound described.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • NIHON MEDI-PHYSICS CO., LTD.
  • 発明者(英語)
  • ONO Masahiro
  • SAJI Hideo
  • IHARA Masafumi
  • MATSUMOTO Hiroki
  • SEKI Ikuya
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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