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RADIOACTIVE IODINE LABELED PYRIDO[1,2-a]BENZOIMIDAZOLE DERIVATIVE COMPOUND NEW

外国特許コード F200010098
整理番号 4933
掲載日 2020年5月18日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2016JP055356
国際公開番号 WO 2016140118
国際出願日 平成28年2月24日(2016.2.24)
国際公開日 平成28年9月9日(2016.9.9)
優先権データ
  • 特願2015-042748 (2015.3.4) JP
発明の名称 (英語) RADIOACTIVE IODINE LABELED PYRIDO[1,2-a]BENZOIMIDAZOLE DERIVATIVE COMPOUND NEW
発明の概要(英語) A radioactive iodine labeled pyrido[1,2-a]benzoimidazole derivative compound represented by a definite general formula or a salt thereof, or a radioactive medicine comprising the same.
従来技術、競合技術の概要(英語) BACKGROUND ART
(AD) in the brain is Alzheimer's disease, amyloid β protein (A β) as a main component (SP) and neuritic plaques, tau protein as a main component accumulation of neurofibrillary tangles (NFT) found. Compared to the accumulation of NFT SP exhibits a high correlation with clinical symptoms, recently, targeted protein with a nuclear medicine diagnostic imaging probes for the development of radioactive molecules has attracted attention.
For example, in patent document 1, have an affinity for a protein with a radioactive iodine rhodanine and thiohydantoin derivatives described in a labeled compound.
In addition, patent document 2, is 3, and tau protein A β compounds having binding to both described. Specifically, the patent document 2, styryl benzimidazole mother nucleus and radioactive iodine labeled compound, in Patent Document 3, benzimidazole pyrimidine and the like are described.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • NIHON MEDI-PHYSICS CO., LTD.
  • 発明者(英語)
  • SAJI Hideo
  • ONO Masahiro
  • IHARA Masafumi
  • SEKI Ikuya
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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