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PAIN-RELATED COMPOUND AND MEDICINAL COMPOSITION

外国特許コード F200010103
整理番号 4355
掲載日 2020年5月18日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP083569
国際公開番号 WO 2015093567
国際出願日 平成26年12月18日(2014.12.18)
国際公開日 平成27年6月25日(2015.6.25)
優先権データ
  • 特願2013-261396 (2013.12.18) JP
発明の名称 (英語) PAIN-RELATED COMPOUND AND MEDICINAL COMPOSITION
発明の概要(英語) The present invention is a pain-related compound, a medicinal composition, and uses thereof. One or multiple embodiments are a compound represented by formula (I), a prodrug thereof, or a pharmaceutically permissible salt thereof.
従来技術、競合技術の概要(英語) BACKGROUND ART
Of the medical condition is pain, several mechanisms of sensory and neural mechanisms involved in complex physiological processes. The pain is neuropathic pain, with actual or potential tissue damage or emotional experience unpleasant sensory defined as, or can be described as such damage.
Classified Pathophysiologically pain, inflammatory pain and neuropathic pain can be classified. Inflammatory pain is, via nociceptors and nociceptive pain, the site of tissue damage caused by inflammatory mediators released in said pain. Inflammatory pain mechanism is thought to be as follows. That is, the tissue is damaged and the inflammation and bradykinin, ATP, protons of the calling party pain material, and/or, prostaglandins, serotonin, histamine, such as the release of inflammatory cytokines, spontaneous pain occurs continuously. Further, due to the sensitivity of the nociceptors hyperalgesia occurs. In addition, as a mechanism of the sensitivity of the nociceptors, ion channels, particularly capsaicin receptor known as TRPV1 has been reported that phosphorylation of the channel.
On the other hand, neuropathic pain is, in the somatosensory is caused by a disease of the nervous system lesions can be defined as pain (2011 year International Society). In Japan, millions of people of the neuropathic pain is presumed the presence of the patient. Which does not involve the excitation of nociceptor pain, central nervous system or peripheral nerves involved in plastic change. As the pathogenesis of neuropathic pain, ectopic firing of a peripheral nerve, peripheral nerve and spinal cord dorsal horn in the neuroanatomical reconstruction, suppression of the descending-suppressing system, activation of glial cells in the spinal cord dorsal horn and the like have been reported.
Is a limited number of publications including Patent Document 1, and a method for treating pain of a composition. In addition, Patent Document 2 is, excess kinase induced suppressed aberrant splicing occurs in the case where a composition for medical use.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYOTO UNIVERSITY
  • NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
  • KAGOSHIMA UNIVERSITY
  • 発明者(英語)
  • HAGIWARA Masatoshi
  • TOYOMOTO Masayasu
  • HOSOYA Takamitsu
  • YOSHIDA Suguru
  • KURIHARA Takashi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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