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Ultrasonic analysis device, ultrasonic analysis method, and storage medium

Foreign code F200010109
File No. 6229
Posted date May 18, 2020
Country China
Application number 201910491191
Gazette No. 110575197
Date of filing Jun 6, 2019
Gazette Date Dec 17, 2019
Priority data
  • P2018-109266 (Jun 7, 2018) JP
Title Ultrasonic analysis device, ultrasonic analysis method, and storage medium
Abstract Provided are an ultrasonic analysis device, an ultrasonic analysis method, and a storage medium for evaluating a lesion of a subchondral bone without being radiated. The ultrasonic analysis device (3)is connected to a transceiving device (2) for transmitting and receiving ultrasonic waves to and from bones and cartilages including subchondral bones (94) located inside a subject (9) and receivingecho signals reflected from the inside of the subject (9), the ultrasonic analysis device (3) being provided with: an image data generation unit (331) for generating ultrasonic image data on the basisof the echo signals; a surface position detection unit (332) that detects the surface position of the subchondral bone (94) on the basis of the ultrasonic image data; a region setting unit (333) thatsets a region to be analyzed in the ultrasound image data with reference to the surface position of the subchondral bone (94); and a feature amount calculation unit (334) that calculates a texture feature amount in the region.
Outline of related art and contending technology BACKGROUND ART
Background
osteoarthritis (OA) is a disease in which a joint is deformed due to wear of cartilage, inflammation occurs in the joint, or pain occurs. If osteoarthritis develops, the natural smooth motion of the joint is impeded and the range of motion is also limited. In particular, if cartilage of the knee joint is worn, it is difficult to perform daily operations such as standing up and walking, and the quality of life is significantly reduced.
As an apparatus for analyzing the state of cartilage, for example, there is an ultrasonic analysis apparatus described in patent document 1. The ultrasonic analysis device described in patent document 1 transmits an ultrasonic signal from an ultrasonic probe in contact with the surface of the knee, and receives an echo signal reflected inside the knee by the ultrasonic probe. The ultrasonic analysis device analyzes the state of the cartilage from the received echo signal.
In recent years, attempts have been made to evaluate lesions of subchondral bone located in a lower layer of cartilage in order to find osteoarthritis at an early stage. From measurements performed by an X-ray Micro CT (Micro-CT, Micro computer tomography) device, it is known that a change occurs in the microstructure of a bone as a lesion of subchondral bone associated with osteoarthritis. Examples of the micro CT parameters of the subchondral bone indicating the change in the microstructure of the bone include the porosity in the subchondral bone plate, the thickness of the subchondral bone, and the bone density in the cancellous bone region. As a technique for evaluating the subchondral bone based on the amplitude of the echo signal of the ultrasonic probe, for example, the techniques of non-patent documents 1 and 2 are known.
documents of the prior art
Patent document 1: japanese laid-open patent publication No. 2010-305
Non-patent document 1: aula AS, Toyras J, Tiitu V, Jurvein JS., "Simultaneous ultrasounded measurement of articular Cartilage and subehondral bone", Osteoarthritis Cartilage, 2010, Vol.18, P1570-6.
non-patent document 2: liukkonen J, Hirvasnimi J, Joukainen A, Penttila P, Viren T, Saarakkala S, Kroger H, Jurvein JS, Toyras J., "Arthroscopic ultrasoundand qualitative assessment of clinical laboratory and clinical laboratory bone: an in vitro and in vivo ease study ", Ultrasound MedBiol, 2013, Vol.39, pl 460-8.
Scope of claims [claim1]
1. An ultrasonic analysis device connected to a transmission/reception device that transmits ultrasonic waves to a bone and a cartilage including a subchondral bone inside a subject and receives an echo signal reflected from the inside of the subject, the ultrasonic analysis device being characterized in that,
the disclosed device is provided with:
An image data generating unit that generates ultrasonic image data from the echo signal;
A surface position detecting unit that detects a surface position of the subchondral bone based on the ultrasonic image data;
an area setting unit that sets an area to be analyzed in the ultrasonic image data with reference to the surface position of the subchondral bone; and
And a feature amount calculation unit for calculating the texture feature amount in the region.

[claim2]
2. An ultrasonic analysis apparatus according to claim 1,
The texture feature amount includes at least one of entropy and correlation in texture analysis of the image data.

[claim3]
3. An ultrasonic analysis apparatus according to claim 2,
The region setting unit sets a plurality of the regions so as to be adjacent to each other in a direction along a sound axis of the ultrasonic wave from the surface position of the subchondral bone;
The feature value calculation unit calculates the texture feature value for each of the plurality of regions.

[claim4]
4. an ultrasonic analysis apparatus according to claim 3,
The regions include a 1 st region corresponding to a superficial portion of the subchondral bone and a 2 nd region located deeper than the 1 st region.

[claim5]
5. An ultrasonic analysis apparatus according to claim 4,
The thickness of the 1 st region along the direction is in the range of 0.3mm to 0.45 mm;
the thickness of the 2 nd region along the direction is in the range of 0.3mm to 0.45 mm.

[claim6]
6. An ultrasonic analysis apparatus according to claim 4 or 5,
The feature value calculation unit calculates the entropy for the 1 st region and calculates the correlation for the 2 nd region.

[claim7]
7. The ultrasonic analysis apparatus according to any one of claims 1 to 6,
The image data generating unit rearranges the ultrasonic image data so that the surface of the subchondral bone is flat.

[claim8]
8. The ultrasonic analysis apparatus according to any one of claims 1 to 7,
The image processing apparatus further includes an output unit that outputs the texture feature amount.

[claim9]
9. An ultrasonic analysis method is characterized in that,
The method comprises the following steps:
Transmitting ultrasonic waves to a bone including subchondral bone and cartilage in an object and receiving an echo signal reflected from the inside of the object;
Generating ultrasonic image data from the echo signal;
Detecting a surface position of the subchondral bone from the ultrasonic image data;
Setting a region to be analyzed in the ultrasonic image data based on the surface position of the subchondral bone; and
And calculating the texture feature quantity in the region.

[claim10]
10. A storage medium characterized in that,
The storage medium stores an ultrasonic analysis program for causing a computer connected to a transmission/reception device that transmits ultrasonic waves to bones including subchondral bone and cartilage in a subject and receives echo signals reflected from the inside of the subject to execute:
Generating ultrasonic image data from the echo signal;
Detecting a surface position of the subchondral bone from the ultrasonic image data;
Setting a region to be analyzed in the ultrasonic image data based on the surface position of the subchondral bone; and
And calculating the texture feature quantity in the region.
  • Applicant
  • FURUNO ELECTRIC CO., LTD.
  • KYOTO UNIVERSITY
  • NATIONAL HOSPITAL ORGANIZATION
  • Inventor
  • KIYAN WATARU
  • KUROKI YUJI
  • NAKAGAWA YASUHIRO
  • MUKAI SHOGO
IPC(International Patent Classification)
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