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TREATMENT AND DIAGNOSIS OF CANCER OR INFECTIOUS DISEASE USING RECOGNITION MECHANISM OF T CELL RECEPTOR NEW

外国特許コード F200010132
掲載日 2020年5月22日
出願国 アメリカ合衆国
出願番号 201716323365
公報番号 20190185539
出願日 平成29年8月4日(2017.8.4)
公報発行日 令和元年6月20日(2019.6.20)
国際出願番号 JP2017028490
国際出願日 平成29年8月4日(2017.8.4)
優先権データ
  • 特願2016-154742 (2016.8.5) JP
発明の名称 (英語) TREATMENT AND DIAGNOSIS OF CANCER OR INFECTIOUS DISEASE USING RECOGNITION MECHANISM OF T CELL RECEPTOR NEW
発明の概要(英語) To provide a therapy and a diagnosis of cancer or an infection using recognition mechanism of a T-cell receptor. An NK cell function enhancer comprises, an active ingredient, a T-cell receptor chimeric protein being a fusion protein of: a T-cell receptor variable region capable of recognizing a cancer-specific antigen or a T-cell receptor variable region capable of recognizing an antigen specific to a pathogen causative of an infection, and an immunoglobulin Fc region, wherein the T-cell receptor chimeric protein binds to an MHC molecular complex of a cancer cell to down-modulate an MHC class I molecule complex, and the cancer cell is killed or damaged by recognition of an NK cell; and an NK cell function enhancer for imparting to an NK cell a function of recognizing a cancer cell or an infected cell infected with a pathogen causative of an infection, which expresses an MHC class I molecule, and killing or damaging the cancer cell or the infected cell by TDCC (T-cell receptor chimeric protein-dependent cellular cytotoxicity) activity.
  • 発明者/出願人(英語)
  • Ogasawara; Koetsu
  • TOHOKU UNIVERSITY
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