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TREATMENT AND DIAGNOSIS OF CANCER OR INFECTIOUS DISEASE USING RECOGNITION MECHANISM OF T CELL RECEPTOR

Foreign code F200010132
Posted date May 22, 2020
Country United States of America
Application number 201716323365
Gazette No. 20190185539
Date of filing Aug 4, 2017
Gazette Date Jun 20, 2019
International application number JP2017028490
Date of international filing Aug 4, 2017
Priority data
  • P2016-154742 (Aug 5, 2016) JP
Title TREATMENT AND DIAGNOSIS OF CANCER OR INFECTIOUS DISEASE USING RECOGNITION MECHANISM OF T CELL RECEPTOR
Abstract To provide a therapy and a diagnosis of cancer or an infection using recognition mechanism of a T-cell receptor. An NK cell function enhancer comprises, an active ingredient, a T-cell receptor chimeric protein being a fusion protein of: a T-cell receptor variable region capable of recognizing a cancer-specific antigen or a T-cell receptor variable region capable of recognizing an antigen specific to a pathogen causative of an infection, and an immunoglobulin Fc region, wherein the T-cell receptor chimeric protein binds to an MHC molecular complex of a cancer cell to down-modulate an MHC class I molecule complex, and the cancer cell is killed or damaged by recognition of an NK cell; and an NK cell function enhancer for imparting to an NK cell a function of recognizing a cancer cell or an infected cell infected with a pathogen causative of an infection, which expresses an MHC class I molecule, and killing or damaging the cancer cell or the infected cell by TDCC (T-cell receptor chimeric protein-dependent cellular cytotoxicity) activity.
  • Inventor, and Inventor/Applicant
  • Ogasawara; Koetsu
  • TOHOKU UNIVERSITY
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