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METHOD FOR REGULATING ANTIGEN-SPECIFIC MHC EXPRESSION 新技術説明会

外国特許コード F200010133
掲載日 2020年5月22日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP003363
国際公開番号 WO 2019151392
国際出願日 平成31年1月31日(2019.1.31)
国際公開日 令和元年8月8日(2019.8.8)
優先権データ
  • 特願2018-015908 (2018.1.31) JP
発明の名称 (英語) METHOD FOR REGULATING ANTIGEN-SPECIFIC MHC EXPRESSION 新技術説明会
発明の概要(英語) Provided is a method for treating and diagnosing autoimmune diseases, organ transplant rejection reactions, and allergic diseases, using a method for regulating antigen-specific MHC expression. Provided is a T cell function inhibitor for inhibiting an autoimmune disease, organ transplant rejection reaction, or allergic disease by regulating the expression of an MHC molecule. The T cell function inhibitor comprises, as an effective component, a T cell receptor chimeric protein that is a fusion protein of the Fc region of an immunoglobulin and the variable region of a T cell receptor that recognizes a complex of an MHC molecule and a specific antigen of the autoimmune disease, or the variable region of a T cell receptor that recognizes a complex of an MHC molecule and a specific antigen that causes the organ transplant rejection reaction, or the variable region of a T cell receptor that recognizes a complex of an MHC molecule and a specific antigen of the allergic disease.
従来技術、競合技術の概要(英語) BACKGROUND ART
Autoimmune disorders, diseases and abnormal response of the immune cells, there is a strong correlation with the MHC type have been reported. In organ transplantation, MHC matching portions of the mold to prevent the rejection has been made the attempt. In this way, in organ transplantation and autoimmune diseases, such as MHC molecule is important.
MHC type of white blood cells known as blood type, and the personal landmark. MHC is, the class I and class II and broadly, the antigen peptide presented on the MHC, MHC complex is formed.
Immune response, cell T-cell receptor (TCR) on the T, antigen binding peptide-specific MHC complex is caused by activated. T cells T-cell receptor is a combination of plays an important role and, in recent years, a patient suffering from a disorder of the T cell receptor repertoires T cell receptor analysis, disease specific T cell receptor has been developed a method for identifying. Further, T-cell receptor fragments using the protein have been reported a method.
T cells in order to adjust the reaction, the reaction of a method of adjusting the cell T although various investigations, T cell immune response and T cell receptor from binding to MHC complex is considered to be caused, for modulating the expression of specific MHC may be performed. The prior art, using an antibody specific MHC expression has been performed. For example, MHC class I molecules mouse, H-2K, D, and L, each of the antibody molecule has been created. Anti-MHC antibody, MHC molecule (LPS) to induce down-regulation is known (Patent Document 1). However, since there is no specific antigenic peptides is assumed that a large side effects.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOHOKU UNIVERSITY
  • 発明者(英語)
  • OGASAWARA Koetsu
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
参考情報 (研究プロジェクト等) Basic Medicine, Immunology
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