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FORMULATION CONTAINING EMRICASAN

外国特許コード F200010144
整理番号 (S2018-0738-N0)
掲載日 2020年6月2日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP025945
国際公開番号 WO 2020004652
国際出願日 令和元年6月28日(2019.6.28)
国際公開日 令和2年1月2日(2020.1.2)
優先権データ
  • 特願2018-125234 (2018.6.29) JP
発明の名称 (英語) FORMULATION CONTAINING EMRICASAN
発明の概要(英語) The present disclosure provides a formulation having improved solubility and/or stability of emricasan. In one embodiment, the present disclosure provides a formulation containing (i) emricasan or a derivative thereof, or a pharmaceutically acceptable salt thereof, or a solvate thereof, (ii) a nonionic surfactant including a polyoxyethylene group, and (iii) a buffering agent that maintains the pH at about 4.5 to about 8.5. The present disclosure also provides a composition in the form of powder for preparing such a formulation at the time of use.
従来技術、競合技術の概要(英語) BACKGROUND ART
Emurikasan is known as pan-caspase inhibitors or suppressing the effect of apoptosis. Emurikasan is, an organic solvent such as ethanol is well soluble in DMSO, water is not easily melted, such as drops of water is less likely to be used as a preparation for use. However, the effectiveness of the formulation against various diseases has been expected. As an example, the failure of the corneal endothelial cell disease is one of the Balanced corneal endothelial dystrophy (Fuchs Endothelial Corneal Dystrophy: FECD) fluoride and the like. FECD is, there is a progressive decrease of the corneal endothelial cell disease, progress to blindness. Is the only current method of treating FECD, corneal transplant surgery and invasive only a new problem of shortage of donor has been desired the development of therapeutics. Is in the in vitro efficacy emurikasan for this disease (Patent Document 1) is shown. In view of these, a water-soluble formulations emurikasan demand is large.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • THE DOSHISHA
  • 発明者(英語)
  • KOIZUMI NORIKO
  • OKUMURA NAOKI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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