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FLUORESCENT-LABELED ANTIBODY OR ANTIBODY FRAGMENT

外国特許コード F200010154
整理番号 (S2018-0340-N0)
掲載日 2020年6月2日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP027279
国際公開番号 WO 2020026733
国際出願日 令和元年7月10日(2019.7.10)
国際公開日 令和2年2月6日(2020.2.6)
優先権データ
  • 特願2018-142089 (2018.7.30) JP
発明の名称 (英語) FLUORESCENT-LABELED ANTIBODY OR ANTIBODY FRAGMENT
発明の概要(英語) Provided is an antibody or antibody fragment that is labeled with a fluorochrome having properties (1) and (2): (1) in the absence of an antigen, the fluorochrome is quenched and, in the presence of the antigen, the quenching of the fluorochrome is released; and (2) the fluorochrome is contained in a compound binding to an amino acid residue in the antibody or antibody fragment.
従来技術、競合技術の概要(英語) BACKGROUND ART
In one of the inventors of the present invention is Sato, recently, while maintaining the ability of the antibody for antigen recognition complementarity determining regions of specific tyrosine residue is chemically modified to develop a technique (Non-Patent Document 1). On the other hand, in the present invention is that one of the ueda, the variable region of the site having the structure of a fluorescent molecule conjugated to the protein molecules are developed. This molecule, a fluorescent molecule in the presence of the antigen of the fluorescence quenching is, in the presence of the antigen Turn-ON type of quenching the fluorescence is released and the sensor, are termed Q-body (Non-Patent Document 2, Patent Document 1, Patent Document 2 and).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO INSTITUTE OF TECHNOLOGY
  • 発明者(英語)
  • SATO SHINICHI
  • NAKAMURA HIROYUKI
  • UEDA HIROSHI
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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