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METHOD FOR ASSESSING SIDE REACTION RISK OF VACCINE

外国特許コード F200010166
整理番号 (S2018-0905-N0)
掲載日 2020年6月3日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP033742
国際公開番号 WO 2020045509
国際出願日 令和元年8月28日(2019.8.28)
国際公開日 令和2年3月5日(2020.3.5)
優先権データ
  • 特願2018-158968 (2018.8.28) JP
発明の名称 (英語) METHOD FOR ASSESSING SIDE REACTION RISK OF VACCINE
発明の概要(英語) To provide a method for assessing the likelihood of a side reaction of a vaccine. A method for assessing the likelihood of a side reaction of a vaccine, said method comprising: (a) a step for measuring microRNA expression level and snRNA expression level in extracellular vesicles sampled from a biological specimen, or measuring the ratio of expression levels of two different microRNAs or snRNAs; and (b) a step for predicting the onset risk of an autoimmune disease from the expression levels or ratio measured above, wherein the microRNA(s) and snRNA(s) are at least one member selected from among miR-16, miR-21, miR-451a and U6.
従来技術、競合技術の概要(英語) BACKGROUND ART
Autoimmune disorders, immune system to recognize the extraneous foreign matter, recognizing its own component caused by the attack. To the central nervous system of an autoimmune disease or acute disseminated encephalomyelitis and such as multiple sclerosis, autoimmune diseases of the peripheral nerves guillain, the valleys of the syndrome and the like. Other tissue as autoimmune diseases, such as rheumatoid arthritis and I diabetes mellitus has been known.
Acute disseminated encephalomyelitis and guillain, autoimmune diseases of the nervous system such as a valley with respect to the syndrome, virus infection or may occur after vaccination. For example, dicaprate guillain virus infection, the valleys of the development of the causal relationship has been reported, as a side effect of the influenza vaccine or vaccine cervical cancer, acute disseminated encephalomyelitis and guillain, the valleys of the syndrome are reported to occur.
After infection and vaccination is an autoimmune disease, produced within the IL-1β, IL-6, such as inflammatory cytokine TNF-α, the blood-brain barrier disruption, T cells or dendritic cells immune cells and the like, from entering into the central nervous system is the main cause. This to the central nervous system as an animal model of autoimmune disease, experimental autoimmune encephalomyelitis (Experimental Autoimmune Encephalomyelitis: EAE) has been known (Non-Patent Document 1, Non-Patent Document 2). Mouse EAE model of autoimmune disease is an experimental system of the general experimental system has been widely used in the study as a.
Extracellular vesicles, vesicle release from various cells and, from the functional cell is transmitted to the cells of the microRNA. In vivo, various extracellular vesicles released from the cells, are enriched in bodily fluids such as blood. From cell to cell and the microRNA is transmitted, is taken into the cytoplasm and to inhibit target gene function, and cytokine production, by changing the amount of expression of other proteins, controls the functions of the various cells. Therefore, an extracellular vesicles, dendritic cells and T cells such as control the function of the immune system have been reported.
Acute disseminated encephalomyelitis and guillain, the risk of autoimmune diseases such as the valleys of the syndrome can be predicted, such as a vaccine of influenza vaccine or vaccination cervical cancer can be refrained. Also, like treatment with early viral infection, autoimmune disease can be preventing the onset.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
  • 発明者(英語)
  • OSHIUMI HIROYUKI
  • ISHIKAWA KANA
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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