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PHYTIC ACID ESTER DERIVATIVE

外国特許コード F200010171
整理番号 (S2018-0906-N0)
掲載日 2020年6月3日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP034220
国際公開番号 WO 2020045653
国際出願日 令和元年8月30日(2019.8.30)
国際公開日 令和2年3月5日(2020.3.5)
優先権データ
  • 特願2018-161944 (2018.8.30) JP
発明の名称 (英語) PHYTIC ACID ESTER DERIVATIVE
発明の概要(英語) The present invention relates to a phytic acid ester derivative and a use of the phytic acid ester derivative. A phytic acid ester derivative according to the present invention has the structure of formula I. [Chemical formula 1] (In formula I, each of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 independently represents H or a structure selected from the group consisting of structures of formula II, structures of formula III and structures of formula IV, excluding the cases where all of the R1-R12 moieties are H.) [Chemical formula 2] (In formula II, -CH2- may optionally be substituted by one or two substituents.) [Chemical formula 3] (In formula III, -CH2-C6H4- may optionally be substituted by one or more substituents.) [Chemical formula 4] (In formula IV, -CH2-CH2- may optionally be substituted by one or more substituents.)
従来技術、競合技術の概要(英語) BACKGROUND ART
Phytic acid (myo - inositol phosphate-1, 2, 3, 4, 5, 6, IP6) within the cells of the human is a mammal such biosynthetic, the number of seeds are also present in the plant tissue is a major storage form of phosphorus. Grain, beans are also be taken from the food or the like. A portion thereof is absorbed, and the like may be captured by pinocytosis cell.
A high concentration of the cancer when added to the cells IP6, cell growth inhibition effect is well studied, has been of interest. JP-2003-238414 is, inositol phosphates acids (inositol 6 phosphoric acid) as an active ingredient is disclosed an anti-tumor agent. Also is IP6, an increase in immunity, kidney stone formation is suppressed, lowering cholesterol, to reduce the risk of coronary artery disease and diabetes and the like are known to have a variety of activity. Vucenik l.et al., Nutrion and Cancer, 2006, 55, 109 is, the anti-oxidant, an increase in immunity, anti-inflammatory, an enzyme and the enzyme modified Phase I Pjase II, cancer gene control, anti-angiogenic, anti-metastatic tumor, induction of apoptosis, cell differentiation increases, such as inhibition of cell proliferation is to have a variety of effects such as IP6 is described.
IP6 In this manner is achieved a beneficial effect of the many, many of the phosphate group 6 from having a negative charge of the cell through the membrane is difficult for, is limited in the amount of cells is IP6. Chelating with the metal IP6 also has a property of blocking the absorption of the mineral body, side effects due to the ingestion of large quantities have been noted.
Is disclosed in JP-2009-541222, any combination of the IP-6, a pharmaceutically acceptable salt, or a pharmaceutically acceptable derivative thereof, an effective amount of a pharmaceutical composition comprising the step of administering to the mammal, ionizing radiation exposure in a mammal, short-term acute health and method for preventing or treating affected (claim 1) is described. Is disclosed in JP-2009-541222 paragraph 0015, " is the object of the present application and/or pyrophosphoric acid as well as IP-6 inositol for derivatives thereof, those skilled in the art, ' 6 inositol phosphate, IP-6, and its analogs are entered as a drug test. One of the challenge 1, to facilitate the passage of molecules into cells in order, a phosphate protecting group in the cover. (DOE report of 13 July 2005) ' has been concluded. And/or pyrophosphoric acid as well as IP-6 and its derivatives containing inositol, the effect as the current protection concept that is not suggested. " In the drawing. IP6 In the cell in order to facilitate the passage of molecules to, phosphate protecting group is referred to as covering. However, it is described that, in particular phosphate protecting groups such as any one of the cover, even if the protecting group is covered with a phosphate compound added into the cell is actually of one of the molecules is promoted, the compound into the cell in the cell has what function is not at all suggested.
IP6 Poor uptake into cells, is limited in the amount, and in spite of the problem, the concrete method to solve the problem has not been provided.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
  • 発明者(英語)
  • FUJITA MIKAKO
  • OTSUKA MASAMI
  • OHSUGI TAKEO
  • TATEISHI HIROSHI
  • MURAO NAOKI
  • MASUNAGA TAKUYA
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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