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INDUCER OF CARDIAC ABILITY TO SYNTHESIZE ACETYLCHOLINE 新技術説明会

外国特許コード F200010179
整理番号 (NMS-0170),S2018-0919-C0
掲載日 2020年7月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP038293
国際公開番号 WO 2020067485
国際出願日 令和元年9月27日(2019.9.27)
国際公開日 令和2年4月2日(2020.4.2)
優先権データ
  • 特願2018-185112 (2018.9.28) JP
発明の名称 (英語) INDUCER OF CARDIAC ABILITY TO SYNTHESIZE ACETYLCHOLINE 新技術説明会
発明の概要(英語) A compound represented by formula (1), a salt thereof or a solvate of the same [in formula (1), R1 represents a linear or branched alkyl group having 2 to 10 carbon atoms, a linear or branched alkyl group having 1 to 10 carbon atoms in which one or more hydrogen atoms are substituted by carboxy groups, or an aryl group having 6 to 20 carbon atoms, each group being optionally substituted].
従来技術、競合技術の概要(英語) BACKGROUND ART
The inventors have found that, so far, to produce muscle acetylcholine, a mechanism to prevent damage to the heart muscle by oxidative stress (non-neuronal myocardial cholinergic system) is found, has been reported (for example, see Non-Patent Document 1).
The inventors have also, to enhance the production of acetylcholine from the heart and in genetically engineered mice, post-myocardial infarction and myocardial is decreased and cell death, survival rates after myocardial infarction of the mouse 2 of the wild-type mice revealed times or more (for example, see Non-Patent Document 2).
Incidentally, nitrogen monoxide (NO) acetylcholine in vivo to promote the generation of known. Is NO, after the synthesis in the cell body is circulated, functions as a second messenger. NO in the cell to activate the guanylate cyclase, cyclic GMP production (cGMP). In humans, (vasodilator) cGMP is vasorelaxant by causing, lowering of blood pressure can have functions such as are known.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIPPON MEDICAL SCHOOL FOUNDATION
  • 発明者(英語)
  • KAKINUMA Yoshihiko
  • NAKAMURA Shigeo
国際特許分類(IPC)

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