Top > Search of International Patents > INDUCER OF CARDIAC ABILITY TO SYNTHESIZE ACETYLCHOLINE

INDUCER OF CARDIAC ABILITY TO SYNTHESIZE ACETYLCHOLINE meetings

Foreign code F200010179
File No. (NMS-0170),S2018-0919-C0
Posted date Jul 27, 2020
Country WIPO
International application number 2019JP038293
International publication number WO 2020067485
Date of international filing Sep 27, 2019
Date of international publication Apr 2, 2020
Priority data
  • P2018-185112 (Sep 28, 2018) JP
Title INDUCER OF CARDIAC ABILITY TO SYNTHESIZE ACETYLCHOLINE meetings
Abstract A compound represented by formula (1), a salt thereof or a solvate of the same [in formula (1), R1 represents a linear or branched alkyl group having 2 to 10 carbon atoms, a linear or branched alkyl group having 1 to 10 carbon atoms in which one or more hydrogen atoms are substituted by carboxy groups, or an aryl group having 6 to 20 carbon atoms, each group being optionally substituted].
Outline of related art and contending technology BACKGROUND ART
The inventors have found that, so far, to produce muscle acetylcholine, a mechanism to prevent damage to the heart muscle by oxidative stress (non-neuronal myocardial cholinergic system) is found, has been reported (for example, see Non-Patent Document 1).
The inventors have also, to enhance the production of acetylcholine from the heart and in genetically engineered mice, post-myocardial infarction and myocardial is decreased and cell death, survival rates after myocardial infarction of the mouse 2 of the wild-type mice revealed times or more (for example, see Non-Patent Document 2).
Incidentally, nitrogen monoxide (NO) acetylcholine in vivo to promote the generation of known. Is NO, after the synthesis in the cell body is circulated, functions as a second messenger. NO in the cell to activate the guanylate cyclase, cyclic GMP production (cGMP). In humans, (vasodilator) cGMP is vasorelaxant by causing, lowering of blood pressure can have functions such as are known.
Scope of claims (In Japanese)[請求項1]
 下記式(1)で表される化合物若しくはその塩又はそれらの溶媒和物。
[化1]
(省略)
[式(1)中、R 1は、いずれも置換されていてもよい、炭素数2~10の直鎖状又は分岐鎖状のアルキル基、1個又は複数個の水素原子がカルボキシ基に置換されている直鎖状又は分岐鎖上の炭素数1~10のアルキル基又は炭素数6~20のアリール基を表す。]

[請求項2]
 前記式(1)で表される化合物が下記式(2)で表される化合物である、請求項1に記載の化合物若しくはその塩又はそれらの溶媒和物。
[化2](省略)

[請求項3]
 請求項1又は2に記載の化合物若しくはその塩又はそれらの溶媒和物からなる、心臓アセチルコリン産生能誘導薬。

[請求項4]
 血圧を低下させることなく、又は、心拍数を増加させることなく、心機能を亢進させる、請求項3に記載の心臓アセチルコリン産生能誘導薬。

[請求項5]
 請求項3又は4に記載の心臓アセチルコリン産生能誘導薬と、薬学的に許容される担体とを含む、心臓アセチルコリン産生能誘導用医薬組成物。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NIPPON MEDICAL SCHOOL FOUNDATION
  • Inventor
  • KAKINUMA Yoshihiko
  • NAKAMURA Shigeo
IPC(International Patent Classification)

PAGE TOP

close
close
close
close
close
close