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METHOD FOR SUPPRESSING PROTEIN TRANSLATION REACTION USING STAPLE NUCLEIC ACID NEW

外国特許コード F200010182
整理番号 (S2019-0014-N0)
掲載日 2020年7月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP042049
国際公開番号 WO 2020085510
国際出願日 令和元年10月25日(2019.10.25)
国際公開日 令和2年4月30日(2020.4.30)
優先権データ
  • 特願2018-201074 (2018.10.25) JP
発明の名称 (英語) METHOD FOR SUPPRESSING PROTEIN TRANSLATION REACTION USING STAPLE NUCLEIC ACID NEW
発明の概要(英語) Provided is a method for suppressing protein expression. In this method, protein expression is suppressed by bringing guanine-repeated sequences close to each other to form a guanine quadruplex structure, using oligomers that hybridize to regions near the guanine-repeated sequences of an RNA having a first, a second, a third, and a fourth guanine-repeated sequences (each referred to as a first G sequence, a second G sequence, a third G sequence, and a fourth G sequence).
従来技術、競合技術の概要(英語) BACKGROUND ART
Such as micro-RNA or siRNA expression of various genes is known suppression techniques 1, 2 (Non-Patent Document 1, 2). However, any technique for a simple mechanism may be coupled to the mRNA gene expression in order to exhibit the function of suppressing, an unexpected effect is unavoidable (off, the effect of the target) 3 (Non-Patent Document 3). In addition, for the purpose of improving stability in the cell of the introduced nucleic acid as the use of a modified nucleic acid, RNA or siRNA activity decreases significantly and the effect of the micro, protein expression is not expected to suppress the problem of 4 (Non-Patent Document 4).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KUMAMOTO UNIVERSITY
  • HIROSAKI UNIVERSITY
  • 発明者(英語)
  • KATSUDA Yosuke
  • SATO Shinichi
  • HAGIHARA Masaki
  • IHARA Toshihiro
  • KITAMURA Yusuke
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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