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FUSION PROTEIN AND UTILIZATION THEREOF NEW

外国特許コード F200010191
整理番号 (S2018-1106-N0)
掲載日 2020年7月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP037829
国際公開番号 WO 2020071230
国際出願日 令和元年9月26日(2019.9.26)
国際公開日 令和2年4月9日(2020.4.9)
優先権データ
  • 特願2018-186569 (2018.10.1) JP
発明の名称 (英語) FUSION PROTEIN AND UTILIZATION THEREOF NEW
発明の概要(英語) A fusion protein comprising one of proteins (A) to (C) and a tag protein which undergoes dimerization or polymerization in response to a stimulus. (A) A protein which comprises the amino acid sequence represented by SEQ ID NO: 1; (B) a protein which comprises an amino acid sequence having 70% or more identity to the amino acid sequence represented by SEQ ID NO: 1 and which is capable of forming an aggregate; and (C) a protein which has an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion, substitution, insertion or addition of one to several amino acids and which is capable of forming an aggregate.
従来技術、競合技術の概要(英語) BACKGROUND ART
Neurodegenerative disease amyotrophic lateral sclerosis (hereinafter, also referred to as ALS.) And frontal lobe degeneration (hereinafter, also referred to FTLD.) Are, modified by the brain and spinal cord nerve cells are lost in the cytoplasm, RNA binding protein aggregation (TAR DNA-binding protein of 43kDa) TDP-43 enclosure can be stored as a main component are known. FTLD diseases such as ALS or group, collectively referred to as TDP-43 protein with macular degeneration.
TDP-43 as a main component as a basis for the accumulation of the main enclosure, the TDP-43 TDP-43 closely linked to the development and pathogenesis of protein denaturation involved and expected, operation of the TDP-43, inhibition of the aggregation of the TDP-43, from the viewpoint of the removal of a TDP-43 aggregation, TDP-43 method for the treatment of protein denaturation can be developed that is not expected.
As described above, characterized in that the TDP-43 protein as macular degeneration condition, and accumulation of agglomerate TDP-43, such feature may be reflected in the condition that the model has been proposed (for example, see Patent Document 1.).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION RESEARCH ORGANIZATION OF INFORMATION AND SYSTEMS
  • 発明者(英語)
  • ASAKAWA Kazuhide
  • KAWAKAMI Koichi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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