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MODIFIED CHANNEL RHODOPSIN NEW

外国特許コード F200010194
整理番号 (S2018-1037-N0)
掲載日 2020年7月29日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2019JP036252
国際公開番号 WO 2020059675
国際出願日 令和元年9月15日(2019.9.15)
国際公開日 令和2年3月26日(2020.3.26)
優先権データ
  • 特願2018-176671 (2018.9.20) JP
発明の名称 (英語) MODIFIED CHANNEL RHODOPSIN NEW
発明の概要(英語) The present invention addresses the problem of providing a modified channel rhodopsin capable of opening and closing an ion channel when irradiated with light having different wavelengths, and/or having high ion permeability (optical reactivity). The solution is to substitute a C-terminal region of a channel rhodopsin obtained by substituting an N-terminal region of volvox-derived channel rhodopsin by an N-terminal region of Chlamydomonas reinhardtii -derived channel rhodopsin-1, by a C-terminal region of Chlamydomonas reinhardtii -derived channel rhodopsin-2 or a C-terminal region of Tetraselmis striata -derived channel rhodopsin.
従来技術、競合技術の概要(英語) BACKGROUND ART
Responsive protein gene expression by (channelrhodopsin) neuronal cells, by applying the light to control the response of cells (Optogenetics: genetics light) by optogenetics, the visual function of the reconstruction of the research worldwide is performed and as is generally known, the present inventors, volvox (Volvox carteri) from the distal region of the N of channelrhodopsin, Chlamydomonas, rain hult lichen (Chlamydomonas reinhardtii) from the terminal region-1 may be replaced with N of channelrhodopsin in, the expression on the cell membrane and improving the efficiency in patent document 1 modified channelrhodopsin reported. This modified channelrhodopsin is, by applying the light to induce excitation ion channel can be opened and, in the case of a loss of gene rat retina to restore vision by introducing the inventors of the present invention is successful.
However, the cells of the retina is the original, by opening and closing of ion channels and has a function of excitation and inhibition thereof from, such a native close by the vision system is demanded channelrhodopsin modified. In addition, have been reported so far than channelrhodopsin modified, a high ion permeability is demanded channelrhodopsin modified.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • IWATE UNIVERSITY
  • 発明者(英語)
  • TOMITA Hiroshi
  • SUGANO Eriko
  • TABATA Kitako
  • WATANABE Yoshito
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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