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HYDROPHILIC POLYMER CROSSLINKED NETWORK HYDROGEL AND ACTIVE OXYGEN INHIBITOR NEW

外国特許コード F200010226
整理番号 (S2019-0203-N0)
掲載日 2020年10月28日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2020JP002541
国際公開番号 WO2020158607
国際出願日 令和2年1月24日(2020.1.24)
国際公開日 令和2年8月6日(2020.8.6)
優先権データ
  • 特願2019-013296 (2019.1.29) JP
発明の名称 (英語) HYDROPHILIC POLYMER CROSSLINKED NETWORK HYDROGEL AND ACTIVE OXYGEN INHIBITOR NEW
発明の概要(英語) Provided is a novel hydrophilic polymer crosslinked network hydrogel. Also provided is an active oxygen inhibitor that senses ROS in a place where an excessive amount of ROS are present and releases an antioxidant. The hydrophilic polymer crosslinked network hydrogel comprises manganese tetrakis(4-carboxyphenyl)porphyrin and a linker L, said linker L having a polyethylene glycol chain linking manganese tetrakis(4-carboxyphenyl)porphyrin molecules to each other, and holds manganese tetrakis(4-carboxyphenyl)porphyrin within a network.
従来技術、競合技術の概要(英語) BACKGROUND ART
Active oxygen (ROS) is deeply involved in cerebral infarction, amyotrophic lateral sclerosis (ALS) and inflammatory bowel disease. Antioxidants capable of erasing ROS are currently approved as agents for alleviating these diseases. For example, Edarabone (radicut) is approved as a therapeutic agent for acute cerebral infarction in 2001 since ROS which causes cytotoxicity due to cerebral infarction can be eliminated. In 2015 years, ALS has also been approved as a therapeutic agent for ALS to delay the progression of ALS amyotrophy due to ROS neuronal cell damage. The antioxidant (5-aminosalicylic acid) is used worldwide as a standard therapeutic agent for inflammatory bowel disease caused by excessive ROS generation. However, edaravone has reported side effects such as liver disorder, renal dysfunction, rash, and the like, and pautopsy drugs also have reported side effects such as liver dysfunction, hypersensitivity symptoms such as eosinophils increase, and the like.
The antioxidant is oxidized by ROS to erase ROS. Therefore, the antioxidant is gently oxidized even by molecular oxygen. As a result, ROS is generated from oxygen. Therefore, antioxidants, as well as other agents, need to be delivered to the location where they are needed to suppress side effects. Micelles that sense ROS and release antioxidants are effective strategies. Non-Patent Document 1 describes a novel ROS-responsive polymer micelle encapsulating an antioxidant rutin having a diol group, which focuses on phenylboronic acid (PBA) that forms a reversible bond with diols and cleaves by oxidation, and utilizes a nanoparticle formation technique by self-assembly of a polymer. In other words, we synthesized a polymer in which PBA is introduced into the side chain of a block copolymer composed of polyethylene glycol and polyamino acid derivatives, mixed with rutin, and dialyzed to construct a spherical monodisperse polymer micelle having a diameter of 30 nm. However, the polymer micelle disclosed in Non-Patent Document 1 cannot avoid the possibility that an excessive amount of antioxidant is released.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • THE DOSHISHA
  • 発明者(英語)
  • HITOMI Yutaka
  • OKUDA Natsumi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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