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PARKINSON'S DISEASE THERAPEUTIC NEW

外国特許コード F200010227
整理番号 (S2019-0188-N0)
掲載日 2020年10月28日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2020JP003462
国際公開番号 WO2020158870
国際出願日 令和2年1月30日(2020.1.30)
国際公開日 令和2年8月6日(2020.8.6)
優先権データ
  • 特願2019-014281 (2019.1.30) JP
発明の名称 (英語) PARKINSON'S DISEASE THERAPEUTIC NEW
発明の概要(英語) The purpose in one embodiment of the present invention is to provide a therapeutic for Parkinson's disease, etc. A compound represented by formulas (1), (2), or (8) or a pharmacologically acceptable salt thereof can be used in the treatment of Parkinson's disease, etc. (Each substituent in the formulas is as described in the specification.)
従来技術、競合技術の概要(英語) BACKGROUND ART
Patients with Parkinson's disease are said to be present in Japan, but current drug therapy is mainly a symptom therapy represented by dopamine replacement therapy. Parkinson's disease is thought to be the deficiency of dopamine due to the decrease of dopamine producing neuronal cells. Therefore, there is a desire to develop a drug that can be a fundamental therapeutic agent for Parkinson's disease. The basic therapeutic agent for Parkinson's disease is expected to be utilized in the treatment of Parkinson's syndrome exhibiting the same symptoms as those in Parkinson's disease. (Non-Patent Document 1 ~ 3) has been reported that meloxicam, etc., which are oxicam based non-steroidal anti-inflammatory drugs, exhibit a MPP +-induced neuronal cell death inhibitory effect and a movement disorder alleviation effect in MPTP-administered Parkinson's disease model mice. Therefore, meloxicam is considered to be a candidate drug such as a therapeutic drug for Parkinson's disease, but has problems. For example, meloxicam has a strong COX inhibitory activity and causes side effects such as gastrointestinal disorders, which is undesirable as a therapeutic agent for Parkinson's disease or the like.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KEIO UNIVERSITY
  • ASAHIKAWA MEDICAL UNIVERSITY
  • 発明者(英語)
  • MASHINO Tadahiko
  • OHE Tomoyuki
  • TAKAHASHI Kyoko
  • YASUDA Daisuke
  • TASAKI Yoshikazu
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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