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IMPLANT MATERIAL CONTAINING SURFACE-TREATED AROMATIC POLYETHER KETONE AND MANUFACTURING METHOD THEREFOR NEW

外国特許コード F200010245
整理番号 (S2019-0375-N0)
掲載日 2020年10月30日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2020JP014238
国際公開番号 WO2020203855
国際出願日 令和2年3月27日(2020.3.27)
国際公開日 令和2年10月8日(2020.10.8)
優先権データ
  • 特願2019-066485 (2019.3.29) JP
発明の名称 (英語) IMPLANT MATERIAL CONTAINING SURFACE-TREATED AROMATIC POLYETHER KETONE AND MANUFACTURING METHOD THEREFOR NEW
発明の概要(英語) The present invention addresses the problem of providing, by a method in which an expensive manufacturing apparatus is not required, an implant material having osteoconductivity superior to that of an implant material containing an aromatic polyether ketone. The present invention pertains to: said method including immersing an aromatic polyether ketone in a strong base solution in the absence of a calcium ion, and immersing an aromatic polyether ketone, which is obtained by the immersing, in a liquid containing a phosphorus-containing compound; and an implant material obtained by said method.
従来技術、競合技術の概要(英語) BACKGROUND ART
A titanium alloy or the like is generally used for implants used for cervical vertebrae treatment such as vertebral body spacers. The titanium alloy has high biocompatibility and high osteoconductivity. However, since it is metal, it is highly rigid to the bone and sometimes destroys the bone. Therefore, the aged with weak bone needs to pay attention to the use. Further, since it has magnetism, halation occurs at the time of image diagnosis such as MRI or the like, and is considered to be 1 which is an interference factor of accurate image diagnosis.
In recent years, vertebral body spacers using PEEK (Poly-ether-ether-ketone), which are 1 super engineering plastics, have been developed. It is known that PEEK is very chemically stable and its rigidity is very close to that of human bone, and the possibility of bone destruction is low compared with the titanium vertebral body spacer described above. On the other hand, the osteoconductivity was lower than that of titanium.
On the other hand, various efforts have been made to improve osteoconductivity. For example, a method of depositing a metal ion plasma on a substrate and attaching cells such as osteoblasts thereto (, for example, Japanese Patent Document 1), a method of mixing the metal ion plasma with bioactive fine particle ceramic containing hydroxyapatite (, for example, Japanese Patent Document 2), and a method of forming a metal oxide adhesive layer on a polymer surface (, for example, Japanese Patent Document 3), and the like have been reported. Further, with respect to a spinal cage, (, for example, Patent Document 4), a spinal cage in which a major axis portion extending through bone contact surfaces on both sides of a structural member formed of PEEK or the like is integrally filled with osteoconductive members is reported. Furthermore, there are also a report of a method of supplying a soluble calcium ion source and a soluble phosphate source to a substrate at a predetermined concentration (Patent Document 6), a report of a method of manufacturing a biological implant in which a surface foam is immersed in both a solution containing calcium ions and a solution containing phosphate ions (Patent Document 7), The methods described in Patent Documents 6 and 7 are methods of depositing calcium phosphate or the like on the surface of a substrate and coating the substrate, and there is no chemical bond between the substrate and phosphorus atoms.
These methods have not been used to obtain osteoconductive materials having the same osteoconductive properties as those of titanium. In addition, (Patent Document 5), which has proposed a method of using sodium hydroxide and fluorine gas when imparting hydrophilic functional groups such as carboxyl groups to the surface of PEEK, requires a large capital investment in terms of corrosion resistance and safety of the manufacturing apparatus in order to use dangerous fluorine gas in this manufacturing method. Further, although a method of introducing phosphate groups into the surface of PEEK has been provided, a special technique such as using plasma is required in (Non-Patent Document 1), and a large capital investment is required.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • OKAYAMA UNIVERSITY
  • SHINSHU UNIVERSITY
  • FUKUOKA UNIVERSITY
  • 発明者(英語)
  • OKIHARA, Takumi
  • TAKADA, Yoshiki
  • SAITO, Naoto
  • AOKI, Kaoru
  • NISHIMURA, Naoyuki
  • HANIU Hisao
  • MORIYAMA, Shigeaki
  • UEDA, Katsuya
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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