Top > Search of International Patents > DRUG DELIVERY COMPOSITION

DRUG DELIVERY COMPOSITION

Foreign code F200010249
File No. AF30-05WO
Posted date Oct 30, 2020
Country WIPO
International application number 2020JP014131
International publication number WO2020203816
Date of international filing Mar 27, 2020
Date of international publication Oct 8, 2020
Priority data
  • P2019-069029 (Mar 29, 2019) JP
Title DRUG DELIVERY COMPOSITION
Abstract A drug delivery composition comprising an acid-resistant cell, said acid-resistant cell enclosing a drug therein. An acid-resistant cell enclosing a drug therein, wherein the drug is localized in a sac-like membrane structure of the acid-resistant cell.
Outline of related art and contending technology BACKGROUND ART
In animals with gastrointestinal tract, including humans, ingested from the mouth is sent to the stomach through the esophagus. For example, in oral administration of a drug, especially when the drug contains peptide or protein as a main component, the drug is highly likely to be enzymatically decomposed in the stomach. Also, since the inside of the stomach is strongly acidic, there is a concern that even a drug of a low molecular weight compound is non-enzymatically degraded in the stomach. In addition, even when the acidic compound is desired to be absorbed in the intestine, the acidic compound may be absorbed in the stomach. Therefore, oral administration using capsules that do not dissolve in the stomach but dissolve in the intestine is useful.
Methods of achieving delivery of drugs to the intestines include Technology (, Non-Patent Document 1), which is called bilosome, utilizing the nature that protein B introduced into lipid is stable in the stomach; Rice vaccines (Non-Patent Document 2) utilizing the fact that protein bodies, which are organelles of rice, exhibit resistance to digestive enzymes, or spores vaccines (Non-Patent Document 3) utilizing spores resistant to digestive enzymes, temperature changes, and pH changes are known.
As an object of industrial oral vaccines, yeast is utilized. For example, Patent Document 1 describes an oral vaccine in which an antigenic protein is expressed in yeast cells. Patent Document 1 shows that the yeast cells are lyophilized to digest and degrade in the ileum without digesting in the stomach and jejunum, but release of antigenic protein from yeast depends on the function of digestive enzyme in the small intestine. Patent Document 2 suggests that immunity is induced by transmucosal/oral administration of a yeast strain incorporating an exogenous gene, but also describes that proteins derived from yeast used have antigenic properties.
Scope of claims (In Japanese)[請求項1]
 薬物を内包する耐酸性細胞を含む薬物送達組成物。

[請求項2]
 前記薬物が、前記耐酸性細胞が有する袋状膜構造に局在している、
 請求項1に記載の薬物送達組成物。

[請求項3]
 前記袋状膜構造が、外因性リポソーム、細胞膜、及び細胞小器官からなる群より選択される少なくとも1種である、請求項2に記載の薬物送達組成物。

[請求項4]
 前記細胞小器官が、ミトコンドリア、葉緑体、小胞体、液胞、細胞核、ペルオキシソーム、及びゴルジ体からなる群より選択される少なくとも1種である、請求項3に記載の薬物送達組成物。

[請求項5]
 前記薬物が、低分子化合物、ペプチド、タンパク質、及び核酸からなる群より選択される少なくとも1種である、請求項1~4のいずれか一項に記載の薬物送達組成物。

[請求項6]
 前記薬物が、腸で作用する薬物である、請求項1~5のいずれか一項に記載の薬物送達組成物。

[請求項7]
 前記薬物が、免疫原性を有する薬物である、請求項1~6のいずれか一項に記載の薬物送達組成物。

[請求項8]
 前記耐酸性細胞が、pH7以上で細胞破裂を生じる細胞である、請求項1~7のいずれか一項に記載の薬物送達組成物。

[請求項9]
 前記耐酸性細胞が、pH1~3の酸性条件に耐性を有する細胞である、請求項1~8のいずれか一項に記載の薬物送達組成物。

[請求項10]
 前記耐酸性細胞が、イデユコゴメ綱(Cyanidiophyceae)に属する藻類の細胞である、請求項1~9のいずれか一項に記載の薬物送達組成物。

[請求項11]
 請求項1~10のいずれか一項に記載の薬物送達組成物を含有する、飼料。

[請求項12]
 請求項1~10のいずれか一項に記載の薬物送達組成物を含有する、医薬品。

[請求項13]
 請求項1~10のいずれか一項に記載の薬物送達組成物を含有する、食品。

[請求項14]
 細胞内に薬物を内包する耐酸性細胞。

[請求項15]
 細胞内に薬物を内包する耐酸性細胞であって、前記薬物が、前記耐酸性細胞が有する袋状膜構造に局在している、耐酸性細胞。

[請求項16]
 薬物としてのペプチド若しくはタンパク質と、細胞膜若しくは細胞小器官に対する局在性ペプチド若しくはタンパク質と、を含む融合タンパク質をコードする遺伝子を、耐酸性細胞に導入する工程を含む、
 請求項15に記載の耐酸性細胞の製造方法。

[請求項17]
 耐酸性細胞を含む薬物キャリア。

[請求項18]
 前記耐酸性細胞が、pH7以上で細胞破裂を生じる細胞である、請求項17に記載の薬物キャリア。

[請求項19]
 前記耐酸性細胞が、pH1~3の酸性条件に耐性を有する細胞である、請求項17又は18に記載の薬物キャリア。

[請求項20]
 前記耐酸性細胞が、イデユコゴメ綱(Cyanidiophyceae)に属する藻類の細胞である、請求項17~19のいずれか一項に記載の薬物キャリア。

[請求項21]
 外因性物質を含む耐酸性細胞。

[請求項22]
 前記外因性物質が、前記耐酸性細胞が有する袋状膜構造に局在している、請求項21に記載の耐酸性細胞。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • FUJIWARA Takayuki
  • HIROOKA Shunsuke
  • MIYAGISHIMA Shin-ya
  • OMATSU Tsutomu
IPC(International Patent Classification)
Reference ( R and D project ) CREST Creation of Basic Technology for Improved Bioenergy Production through Functional Analysis and Regulation of Algae and Other Aquatic Microorganisms AREA
Please contact us by E-mail or facsimile if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close