TOP > 外国特許検索 > PROMOTOR FOR PERMEATION INTO CELL LAYER, COMPOSITION FOR FACILITATING DRUG AGENT ABSORPTION, AND PHARMACEUTICAL COMPOSITION

PROMOTOR FOR PERMEATION INTO CELL LAYER, COMPOSITION FOR FACILITATING DRUG AGENT ABSORPTION, AND PHARMACEUTICAL COMPOSITION NEW

外国特許コード F200010255
整理番号 (S2019-0227-N0)
掲載日 2020年11月5日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2020JP012446
国際公開番号 WO2020196315
国際出願日 令和2年3月19日(2020.3.19)
国際公開日 令和2年10月1日(2020.10.1)
優先権データ
  • 特願2019-057323 (2019.3.25) JP
発明の名称 (英語) PROMOTOR FOR PERMEATION INTO CELL LAYER, COMPOSITION FOR FACILITATING DRUG AGENT ABSORPTION, AND PHARMACEUTICAL COMPOSITION NEW
発明の概要(英語) Provided is a technique for promoting permeation of a substance into a cell layer. Provided are: a promotor for permeation into a cell layer, constituted of a compound represented by general formula (1); a composition for facilitating drug agent absorption, containing said promotor for permeation into a cell layer and configured to facilitate drug agent absorption into a living body; and a pharmaceutical composition containing said promotor for permeation into a cell layer, and further containing a drug agent to be absorbed by a living body.
従来技術、競合技術の概要(英語) BACKGROUND ART
In a cell layer forming epithelial tissue or the like, a gap between adjacent cells is sealed by a cell adhesion structure such as a tight junction (TJ: Tight Junction) or the like to fulfill a barrier function against foreign matter. Therefore, the permeability of the intercellular pathway through the intercellular pathway is very limited to maintain the homeostasis of the living body. There is a concept of a drug delivery system (DDS: Drug Delivery System) in which the cell adhesion structure is primarily relaxed to allow a desired substance to permeate through the intercellular pathway, thereby enhancing absorption of a drug or the like into a living body. Some biopharmaceuticals and candidates thereof which are actively developed, such as peptides, proteins, antibodies, vaccines, nucleic acids, etc., have low bioavailability, The development of techniques is desired because the range of applicability of such drugs is widened and the improvement of Quality of Life in a patient is also achieved by non-invasive administration methods such as oral, transdermal, nasal, pulmonary, transmucosal or the like instead of injection administration.
On the other hand, the following Non-Patent Document 6 reports cyclic lipopeptides as antibacterial substances derived from Pseudomonas bacteria.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF TSUKUBA
  • TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES
  • 発明者(英語)
  • USUI Takeo
  • NAGUMO Yoko
  • MUKAIYAMA Minagi
  • HAYASHI Yoshio
  • TANIGUCHI Atsuhiko
  • UCHIYAMA Chihiro
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
この特許について質問等ある場合は、電子メールによりご連絡ください。

PAGE TOP

close
close
close
close
close
close