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METHOD FOR PRODUCING POLYMERIZED POLYPEPTIDE AGGREGATE AND METHOD FOR INCREASING MOLECULAR WEIGHT OF POLYMERIZED POLYPEPTIDE NEW

外国特許コード F210010278
整理番号 (S2019-0398-N0)
掲載日 2021年1月27日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2020JP016297
国際公開番号 WO 2020213568
国際出願日 令和2年4月13日(2020.4.13)
国際公開日 令和2年10月22日(2020.10.22)
優先権データ
  • 特願2019-079549 (2019.4.18) JP
発明の名称 (英語) METHOD FOR PRODUCING POLYMERIZED POLYPEPTIDE AGGREGATE AND METHOD FOR INCREASING MOLECULAR WEIGHT OF POLYMERIZED POLYPEPTIDE NEW
発明の概要(英語) Disclosed is a method for producing a polymerized polypeptide aggregate, said method comprising a step for reacting a polypeptide, which has a tag on the N-terminal side and/or C-terminal side, with a polymerase to give a reaction liquid containing a polymerized polypeptide; a step for freezing the reaction liquid; and a step for thawing the frozen reaction liquid, wherein the polymerase recognizes the tag.
従来技術、競合技術の概要(英語) BACKGROUND ART
Vaccines, which have been developed to cope with infectious diseases, are mainly attenuated live vaccines and inactivated vaccines. recently, the demand for component vaccines based on proteins produced by recombinant techniques has been increasing. Component vaccines using recombinant proteins are safer than conventional live attenuated vaccines and inactivated vaccines, and are expected to cope with infectious diseases which cannot be handled by conventional vaccines, and have low immunogenicity. One strategy for improving immunogenicity is to increase the molecular weight of the antigen.
As a method of increasing the molecular weight of the antigen, there is a method of using a chemical crosslinking agent. For example, as reported that a highly crosslinked protein polymer can be obtained by HRP enzymatic reaction by introducing Y-tag to both ends of N / C of a monomer protein, an enzyme can be used as a chemical crosslinking agent and polymerized to increase the molecular weight of the antigen.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KAGOSHIMA UNIVERSITY
  • KYUSHU UNIVERSITY
  • 発明者(英語)
  • MIYATA Takeshi
  • KURIHARA Koichi
  • SATO Keita
  • KAMIYA Noriho
  • MINAMIHATA Kosuke
  • KUSAKABE Takahiro
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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