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ANTITHROMBOGENIC MATERIAL, PRODUCTION METHOD OF ANTITHROMBOGENIC MATERIAL, ARTIFICIAL ORGAN, AND ANTITHROMBOGENICITY IMPARTING AGENT NEW 新技術説明会

外国特許コード F210010281
整理番号 (FU-331)
掲載日 2021年1月28日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2020JP016144
国際公開番号 WO 2020213529
国際出願日 令和2年4月10日(2020.4.10)
国際公開日 令和2年10月22日(2020.10.22)
優先権データ
  • 特願2019-077056 (2019.4.15) JP
発明の名称 (英語) ANTITHROMBOGENIC MATERIAL, PRODUCTION METHOD OF ANTITHROMBOGENIC MATERIAL, ARTIFICIAL ORGAN, AND ANTITHROMBOGENICITY IMPARTING AGENT NEW 新技術説明会
発明の概要(英語) The present disclosure provides an antithrombogenic material having a substrate and a surface modified layer provided on at least a portion of the substrate, wherein: the surface modified layer includes a block copolymer having a first structural unit having, in the side chain thereof, at least one selected from the group consisting of an alkylene chain and a halogenated alkylene chain, and a second structural unit represented by general formula (1); a unit including the first structural unit has a weight average molecular weight of 9,000-15,000; and a unit including the second structural unit has a weight average molecular weight of 10,000-40,000. In general formula (1), R1 represents a hydrogen atom or a methyl group, R2 represents a methyl group or an ethyl group, n represents an integer of 1-6, m represents an integer of 1-100, and x represents an integer of 1 or more.
従来技術、競合技術の概要(英語) BACKGROUND ART
Medical materials are often composed of extracorporeal materials, and are recognized as foreign substances by biomolecules. When the biological tissue and the material are brought into contact with each other, non-specific adsorption and denaturation of the protein to the surface of the material occur, and activation of the coagulation system, platelet system, and the like may occur. Therefore, a method of forming a layer on the surface of a base material of a medical material to impart biocompatibility (, for example, antithrombotic), has been studied (, for example, Patent Document 1).
In addition, in order to apply a temperature-responsive polymer compound to medical devices, polymers having both biocompatibility and temperature-responsive properties have been studied (, for example, Patent Document 2). Patent Document 2 describes that the polymer includes a repeating unit derived from (meth) acrylate having a polyethylene oxide chain in a side chain, and that the polymer may be a copolymer. On the other hand, Patent Document 2 does not examine the influence of the weight average molecular weight or the like of each unit constituting the copolymer.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KYUSHU UNIVERSITY
  • FUKUOKA UNIVERSITY
  • 発明者(英語)
  • TANAKA Masaru
  • YAO Shigeru
  • HIRAI Sho
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DJ DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JO JP KE KG KH KN KP KR KW KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN WS ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG

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